产品介绍
miRNA抑制剂可以特异、高效地抑制生物体内源性miRNA的活性,是研究miRNA功能缺失的重要工具。GeneCopoeia提供慢病毒或非病毒载体的miArrest™ miRNA抑制剂表达克隆和化学合成的miRNA抑制剂。 |
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miArrest™ miRNA抑制剂克隆可以特异性地结合目的miRNA,瞬时和稳定地抑制miRNA的功能,采用H1或者U6启动子驱动转录可以保证在大多数哺乳动物细胞中高水平表达。 |
优势
覆盖面广
- 针对所有已知的人、小鼠和大鼠miRNA
灵活的载体选择
- 慢病毒载体可转导普通细胞和难转染、未分化细胞
- 非病毒载体可进行稳定或瞬时转导
先进可靠的设计
- 表达框经过专利算法设计并经过严格的实验验证
抑制性能优越
- 与其他化学合成的miRNA抑制剂相比具有更强、更持久的抑制作用和极低的细胞毒性(参照表1)
- 采用H1或U6启动子保证在大多数哺乳动物细胞中高水平表达
高通量兼容
- 快速简便的实验设计
- 可同时检测多个样
HEK293细胞中共转染miR-125a 抑制剂表达质粒 (GeneCopoeia HmiR-AN0094-AM01) 、miR-125a 前体表达质粒(GeneCopoeia HmiR0309-MR03) 和miR-125a的靶标克隆质粒(GeneCopoeia HmiT019205-MT02:将LIN28 的3’UTR克隆到Gaussia荧光素酶-碱性磷酸酶双报告载体)。转染24小时后检测报告基因Gaussia 荧光素酶和参照基因碱性磷酸酶的活性。只转染Gluc-LIN28-3’-UTR质粒的细胞中Gaussia 荧光素酶与碱性磷酸酶活性比值设为1 (左数第一条柱),用来标准化其他细胞样品中的报告基因活性。结果表明miR-125a抑制了Gluc-LIN28-3’-UTR中Gluc 70%以上的活性(左数第二条柱)。这种抑制效应可被导入的不同剂量的miR-125a抑制剂表达质粒特异性的阻遏。转染100 ng 抑制剂表达质粒时,细胞内报告基因/参照基因活性比值(右数第一条)已超出单独转染Gluc-LIN28-3’-UTR报告质粒的对照组。这说明miR-125a抑制剂可以阻遏外源和内源性的miR-125a对靶标基因的抑制,提高GLuc-LIN28-3’-UTR转录本的翻译水平。 |
图1. 不同剂量miArrest™ miRNA抑制剂克隆对靶miRNA抑制作用的对比 |
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表1. 基于克隆表达载体的和化学合成的miRNA抑制剂的比较 |
miRNA 抑制剂克隆导入细胞后表达的miRNA抑制剂(miArrest)特异地结合它们的靶miRNA。miRNA抑制剂转录后折叠形成一个稳定的陷阱结构,可以结合两分子靶miRNA。 miArrest™高效、特异地结合细胞内成熟的靶miRNA,阻止了miRNA对靶标mRNA的降解或者翻译抑制,上调miRNA靶标基因的表达。 独特的载体设计确保最大的特异性、抑制强度、抑制作用持久度和最低的脱靶效应。 |
图2. miRNA抑制剂表达克隆的作用机理 |
载体
miRNA抑制剂表达克隆载体
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慢病毒载体的miRNA抑制剂表达克隆 |
GeneCopoeia提供客户定制的慢病毒载体miRNA抑制剂表达克隆,周期2-5周。
化学合成的miRNA抑制剂
需要优化设计的miRNA抑制剂,点击了解更多
克隆套装
miRNA抑制剂表达克隆套装
GeneCopoeia除了提供单个克隆,也提供预制和定制的miRNA抑制剂表达克隆套装。了解详情请点击联系我们或拨打400-6020-200。
货号 | 产品描述 | miRNA | 载体 | 价格 |
MIC-HG-AM03 | Human whole genome miRNA inhibitor clone set (lentiviral) | 994 | pEZX-AM03 | Inquire |
Various | Human cancer miRNA inhibitor clone sets (lentiviral) | Various View all cancer sets below |
pEZX-AM03 | Inquire |
MIC-MG-AM03 | Mouse genome miRNA inhibitor clone set (lentiviral) | 307 | pEZX-AM03 | Inquire |
MIC-RG-AM03 | Rat genome miRNA inhibitor clone set (lentiviral) | 222 | pEZX-AM03 | Inquire |
人癌症miRNA抑制剂克隆套装(慢病毒载体)
货号 | 产品描述 | 癌症 | miRNA | 价格 |
MIC-HCY-AM03 | Human bladder cancer miRNA inhibitor clone set | Bladder cancer | 63 | Inquire |
MIC-HCN-AM03 | Human brain cancer miRNA inhibitor clone set | Brain cancer | 206 | Inquire |
MIC-HCB-AM03 | Human breast cancer miRNA inhibitor clone set | Breast cancer | 158 | Inquire |
MIC-HCV-AM03 | Human cervical cancer miRNA inhibitor clone set | Cervical cancer | 26 | Inquire |
MIC-HCI-AM03 | Human cholangiocarcinoma miRNA inhibitor clone set | Cholangiocarcinoma | 25 | Inquire |
MIC-HCC-AM03 | Human colorectal cancer miRNA inhibitor clone set | Colorectal cancer | 175 | Inquire |
MIC-HCW-AM03 | Human endometrial cancer miRNA inhibitor clone set | Endometrial cancer | 86 | Inquire |
MIC-HCG-AM03 | Human gastric cancer miRNA inhibitor clone set | Gastric cancer | 76 | Inquire |
MIC-HCT-AM03 | Human head and neck cancer miRNA inhibitor clone set | Head and Neck cancer | 188 | Inquire |
MIC-HCH-AM03 | Human hepatocellular carcinoma miRNA inhibitor clone set | Hepatocellular Carcinoma | 170 | Inquire |
MIC-HCK-AM03 | Human kidney cancer miRNA inhibitor clone set | Kidney cancer | 67 | Inquire |
MIC-HCX-AM03 | Human leukemia miRNA inhibitor clone set | Leukemia | 163 | Inquire |
MIC-HCL-AM03 | Human lung cancer miRNA inhibitor clone set | Lung cancer | 178 | Inquire |
MIC-HCZ-AM03 | Human lymphoma miRNA inhibitor clone set | Lymphoma | 112 | Inquire |
MIC-HCM-AM03 | Human melanoma miRNA inhibitor clone set | Melanoma | 131 | Inquire |
MIC-HCE-AM03 | Human mesothelioma miRNA inhibitor clone set | Mesothelioma | 21 | Inquire |
MIC-HCR-AM03 | Human myeloma miRNA inhibitor clone set | Myeloma | 45 | Inquire |
MIC-HCO-AM03 | Human ovarian cancer miRNA inhibitor clone set | Ovarian cancer | 174 | Inquire |
MIC-HCP-AM03 | Human pancreatic cancer miRNA inhibitor clone set | Pancreatic cancer | 166 | Inquire |
MIC-HCA-AM03 | Human pituitary adenoma miRNA inhibitor clone set | Pituitary Adenoma | 33 | Inquire |
MIC-HCQ-AM03 | Human prostate cancer miRNA inhibitor clone set | Prostate cancer | 153 | Inquire |
MIC-HCS-AM03 | Human sarcoma miRNA inhibitor clone set | Sarcoma | 27 | Inquire |
MIC-HCJ-AM03 | Human thyroid carcinoma miRNA inhibitor clone set | Thyroid Carcinoma | 55 | Inquire |
MIC-HCU-AM03 | Human uterine leiomyoma miRNA inhibitor clone set | Uterine Leiomyoma | 40 | Inquire |
相关产品
发表的文章
<2018
- Jia, B., et al. (2018). The role of miR-766-5p in cell migration and invasion in colorectal cancer. Experimental and Therapeutic Medicine DOI: 10.3892/etm.2018.5716 [miArrest™ miR-766-5p inhibitor clone]
- Cao, M-Q., et al. (2018). miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a. Journal of Hematology & Oncolog DOI: 10.1186/s13045-018-0555-y [miArrest™ miR-182-5p miRNA lentiviral inhibitor clone]
- Liang, L., et al. (2018). microRNA-1297 involves in the progression of oral squamous cell carcinoma through PTEN. Saudi Journal of Biological Sciences DOI: 10.1016/j.sjbs.2018.01.013 [miArrest™ miR-1297 inhibitor clone]
- Srivistava, A., et al. (2018). Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor. Journal of Molecular Medicine DOI: 10.1007/s00109-018-1623-z [miArrest™ miRNA inhibitor clone]
- Li, W., et al. (2018). Sirtuin7 has an oncogenic potential via promoting the growth of cholangiocarcinoma cells. Biomedicine and Pharmacotherapy DOI: 10.1016/j.biopha.2018.02.007 [miArrest™ miR-125b-5p miRNA inhibitor clone]
- Long, J., and Pi, X (2018).LncRNA-MEG3 suppresses the proliferation and invasion of melanoma by regulating CYLD expression mediated by sponging miR-499-5p. Biomed Research International [miArrest™ miR-499 inhibitor clone]
- Chinnappan, M., et. al. (2018). Network of MicroRNAs Mediate Translational Repression of Bone Morphogenetic Protein Receptor‐2: Involvement in HIV‐Associated Pulmonary Vascular Remodeling. Journal of the American Heart Association DOI: 10.1161/JAHA.117.008472 [synthetic single‐strand miRNA antagomirs against miR‐19a, miR‐21, and miR‐301a]
- Cai, T., et al. (2018). Long noncoding RNA MALAT1 knockdown reverses chemoresistance to temozolomide via promoting microRNA-101 in glioblastoma. Cancer Medicine DOI: 10.1002/cam4.1384 [miArrest™ miR-101 inhibitor clone]
- Zhang, J-X., et al. (2018). LINC01410-miR-532-NCF2-NF-kB feedback loop promotes gastric cancer angiogenesis and metastasis. Oncogene DOI: 10.1038/s41388-018-0162-y [miArrest™ miR-101 inhibitor clone]
- Zhang, J., et al. (2018). Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression. Molecular Medicine Reports DOI: 10.3892/mmr.2018.8714 [miArrest™ miR-614 inhibitor clone]
- Chen, M., et al. (2018). microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression. Oncology Letters DOI: 10.3892/ol.2018.8218 [miArrest™ miR-544 inhibitor clone]
- Xu, R., et al. (2018). LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells. Cancer Cell International DOI: 10.1186/s12935-018-0540-0 [miArrest™ miR-200c inhibitor clone]
- Han, S., et al. (2018). MicroRNA-577 inhibits the migration and invasion of hepatocellular carcinoma cells by targeting homeobox A1. Oncology Reports DOI: 10.3892/or.2018.6388 [miArrest™ miR-577 inhibitor clone]
- Cui, H-B, et al. (2018). MiR-208a enhances cell proliferation and invasion of gastric cancer by targeting SFRP1 and negatively regulating MEG3. The International Journal of Biochemistry & Cell Biology DOI: 10.1016/j.biocel.2018.06.004 [miArrest™ miR-208a inhibitor clone]
- Ma, W., et al. (2018). MicroRNA-302c represses epithelial–mesenchymal transition and metastasis by targeting transcription factor AP-4 in colorectal cancer. Biomedicine & Pharmacotherapy DOI: 10.1016/j.biopha.2018.06.025 [miArrest™ miR-302c inhibitor clone]
- Koeck, I, et al. (2018). Tumor Necrosis Factor-α Initiates miRNA-mRNA Signaling Cascades in Obstruction-Induced Bladder Dysfunction. The American Journal of Pathology DOI: 10.1016/j.ajpath.2018.05.008 [miArrest™ lentiviral inhibitor clones]
- Seeley, J.J., et al. (2018). Induction of innate immune memory via microRNA targeting of chromatin remodelling factors. Nature DOI: 10.1038/s41586-018-0253-5 [miArrest™ miR-222, miR-146a lentiviral inhibitor clones]
- Yang, L., et al. (2018). The tumor suppressive miR -302c -3p inhibits migration and invasion of hepatocellular carcinoma cells by targeting TRAF4. Journal of Cancer DOI: 10.7150/ jca .25569 [miArrest™ miR-302c inhibitor clone]
- Peng, J., et al. (2018). MicroRNA-26a protects vascular smooth muscle cells against H2O2-induced injury through activation of the PTEN/AKT/mTOR pathway. International Journal of Molecular Medicine DOI: 10.3892/ijmm.2018.3746 [miArrest™ miR-26a inhibitor clone]
- Chen, B., et al. (2018). circEPSTI1 as a Prognostic Marker and Mediator of Triple -Negative Breast Cancer Progression. Theranostics DOI: 10.7150/ thno .24106 [miArrest™ inhibitor clones]
- Rajan, S. and Panzade, G. (2018). miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin. Journal of Endocrinology DOI: 10.1530/JOE-17-0387 [miArrest™ miR-876-3p lentiviral inhibitor clone]
- Zhao, W., et al. (2018). MicroRNA-29a contributes to intracranial aneurysm by regulating the mitochondrial apoptotic pathway. Molecular Medicine Reports DOI: 10.3892/mmr.2018.9257 [miArrest™ miR-29a inhibitor clone]
- Sun, X., et al. (2018). microRNA-761 regulates glycogen synthase kinase 3β expression and promotes the proliferation and cell cycle of human gastric cancer cells. Oncology Letters DOI: 10.3892/ol.2018.9133 [miArrest™ miR-761 inhibitor clone]
- Xu, Y., et al. (2018). MiR‐616‐3p modulates cell proliferation and migration through targeting tissue factor pathway inhibitor 2 in preeclampsia. Cell Proliferation DOI: 10.1111/cpr.12490 [miArrest™ miR-616-3p inhibitor clone]
- Zhang, L., et al. (2018). miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP. Biomedicine & Pharmacotherapy DOI: 10.1016/j.biopha.2018.07.155 [miArrest™ miR-23c inhibitor clone]
- Wang, Z., et al. (2018). Down-regulation of microRNA-429 contributes to angiotensin II-induced profibrotic effect in rat kidney. American Journal of Physiology-Renal Physiology DOI: 10.1152/ajprenal.00478.2017 [miArrest™ miR-429 inhibitor clone]
- Wang, Y., et al. (2018). Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/β-catenin signal pathway in hepatocellular carcinoma. Cell dEath & Disease DOI: 10.1038/s41419-018-0937-7 [miArrest™ miR-485-5p inhibitor clone]
- Bai, X-Z., et al. (2018). MicroRNA-138 Aggravates Inflammatory Responses of Macrophages by Targeting SIRT1 and Regulating the NF-κB and AKT Pathways. Cellular Physiology and Biochemistry DOI: 10.1159/000492988 [miArrest™ miR-138 inhibitor clone]
- Li, X., et al. (2018). Long noncoding RNA LINC00978 promotes cell proliferation and invasion in non-small cell lung cancer by inhibiting miR-6754-5p. Molecular Medicine Reports DOI: 10.3892/mmr.2018.9463 [miArrest™ miR-138 inhibitor clone]
- Li, T., et al. (2018). MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop. Journal of Experimental & Clinical Cancer Research DOI: 10.1186/s13046-018-0879-z [miArrest™ miR-452 inhibitor clone]
- Wang, J., et al. (2018). MicroRNA-182-5p attenuates cerebral ischemia-reperfusion injury by targeting Toll-like receptor 4. Biochemical and Biophysical Research Communications DOI: 10.1016/j.bbrc.2018.09.165 [miArrest™ miR-182-5p inhibitor clone]
- Tan, J., et al. (2018). MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation. International Journal of Biological Macromolecules DOI: 10.1016/j.ijbiomac.2018.10.032 [miArrest™ miR-645 inhibitor clone]
- Muhammad, S., et al. (2018). miRNA-30d serves a critical function in colorectal cancer initiation, progression and invasion via directly targeting the GNA13 gene. Experimental and Therapeutic Medicine DOI: 10.3892/etm.2018.6902 [miArrest™ miR-30d inhibitor clone]
<2017
- Jiang, X., et al. (2017). Overexpression of miR-92a promotes the tumor growth of osteosarcoma by suppressing F-box and WD repeat-containing protein 7. Gene DOI: 10.1016/j.gene.2017.01.002. [miArrest™ miR-92a inhibitor clone]
- Men, R., et a. (2017). MircoRNA-145 promotes activation of hepatic stellate cells via targeting krüppel-like factor 4. Scientific Reports DOI: 10.1038/srep40468 [miArrest™ miR-145 inhibitor clone]
- Hou, S., et al. (2017). MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells. Biochemical and Biophysical Research Communications DOI: 10.1016/j.bbrc.2017.01.085 [miArrest™ miR-939 inhibitor clone]
- Wang, et al. (2017). MicroRNA-199a-5p promotes tumour growth by dual-targeting PIAS3 and p27 in human osteosarcoma. Scientific Reports DOI: 10.1038/srep41456 [miArrest™ miR-199a inhibitor clone]
- Hu, S., et al. (2017). MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2. Oncology Reports DOI: 10.3892/or.2017.5421 [miArrest™ miR-520c inhibitor clone]
- Lin, Y., et al. (2017). microRNA-489 Plays an Anti-Metastatic Role in Human Hepatocellular Carcinoma by Targeting Matrix Metalloproteinase-7. Translational Oncology DOI: 10.1016/j.tranon.2017.01.010 [miArrest™ miR-489 inhibitor clone]
- He, Z., et al. (2017). miR-296 inhibits the metastasis and epithelial-mesenchymal transition of colorectal cancer by targeting S100A4.BMC Cancer DOI: 10.1186/s12885-017-3121-z [miArrest™ miR-296 inhibitor clone]
- Imani, S., et al. (2017). MicroRNA-34a targets epithelial to mesenchymal transition- inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion. Oncotarget February 9, 2017 [miArrest™ miR-34a inhibitor clone]
- LI, P., et al. (2017). MicroRNA-130b promotes cell migration and invasion by inhibiting peroxisome proliferator-activated receptor-γ in human glioma. Oncology Letters DOI: 10.3892/ol.2017.5760 [miArrest™ miR-130b inhibitor clone]
- Bao, Q., et al. (2017). MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor. Life Siences DOI: 10.1016/j.lfs.2017.03.006 [miArrest™ miR-297 inhibitor clone]
- Pan, T., et al. (2017). miR-944 inhibits metastasis of gastric cancer by preventing the epithelial–mesenchymal transition via MACC1/Met/AKT signaling. FEBS Open Bio DOI: 10.1002/2211-5463.12215 [miArrest™ miR-944 inhibitor clone]
- Chang, W., et al. (2017). MicroRNA-33a promotes cell proliferation and inhibits apoptosis by targeting PPARα in human hepatocellular carcinoma. Experimental and Therapeutic Medicine DOI: 10.3892/etm.2017.4236 [miArrest™ miR-33a inhibitor clone]
- Zhang, X., et al. (2017). miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2. Cell Death & Disease DOI: 10.1038/cddis.2017.146 [miArrest™ miR-146a inhibitor clone]
- LIqIANG, W., et al. (2017). miR-944 inhibits cell migration and invasion by targeting MACC1 in colorectal cancer. Oncology Reports DOI: 10.3892/or.2017.5611 [miArrest™ miR-944 inhibitor clone]
- Cui, A., et al. (2017). Downregulation of miR-493 promoted melanoma proliferation by suppressing IRS4 expression. Tumor Biology DOI: May 5, 2017 [miArrest™ miR-493 inhibitor clone]
- Li, H., et al. (2017). MicroRNA-17-5p inhibits proliferation and triggers apoptosis in non-small cell lung cancer by targeting transforming growth factor β receptor 2. Experimental and Therapeutic Medicine DOI: 10.3892/etm.2017.4347 [miArrest™ miR-17-5p inhibitor clone]
- Jiang, C., et al.(2017). MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4. Oncology Reports DOI: 10.3892/or.2017.5641 [miArrest™ miR-212 inhibtor clone]
- Liu, H., et al. (2017). MicroRNA-216a promotes the metastasis and epithelial–mesenchymal transition of ovarian cancer by suppressing the PTEN/AKT pathway. Onco Targets Ther. DOI: 10.2147/OTT.S114318 [mArrest™ miR-216a inhibitor clone]
- Yue, J., et al. (2017). MicroRNA-335-5p Plays Dual Roles in Periapical Lesions by Complex Regulation Pathways. Journal of Endodontics DOI: 10.1016/j.joen.2017.03.018 [miArrest™ miR-335-5p inhibitor clone]
- Zhu, J., et al. (2017). miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1–STAT1/c-Fos pathway. Journal of Cellular and Molecular Medicine DOI: 10.1111/jcmm.13201 [miArrest™ miR-181a, and mmu-miR-150 inhibitor clones]
- Xu, Q., et al. (2017). MicroRNA-1296 inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting SRPK1-mediated PI3K/AKT pathway. Molecular Cancer DOI: 10.1186/s12943-017-0675-y [miArrest™ miR-1296 inhibitor clone]
- Liang, S., et al. (2017). miR-663b promotes tumor cell proliferation, migration and invasion in nasopharyngeal carcinoma through targeting TUSC2 . Experimental and Therapeutic Medicine DOI: 10.3892/etm.2017.4608 [miArrest™ miR-663b inhibitor clone]
- Wang, J., et al. (2017). miR-629-3p may serve as a novel biomarker and potential therapeutic target for lung metastases of triple-negative breast cancer. Breast Cancer Research DOI: 10.1186/s13058-017-0865-y [miArrest™ miR-629-3p lentiviral inhibitor clone]
- Ma, F., et al. (2017). MicroRNA-19a promotes nasopharyngeal carcinoma by targeting transforming growth factor β receptor 2. Experimental and Therapeutic Medicine DOI: 10.3892/etm.2017.4655
- Li, Y., et al. (2017). miR-489 inhibits proliferation, cell cycle progression and induces apoptosis of glioma cells via targeting SPIN1-mediated PI3K/AKT pathway. Biomedicine & Pharmacotherapy DOI: 10.1016/j.biopha.2017.06.058 [miArrest™ miR-489 inhibitor clone]
- Cao, X., et al. (2017). miRNA-504 inhibits p53-dependent vascular smooth muscle cell apoptosis and may prevent aneurysm formation. Molecular Medicine Reports DOI: 10.3892/mmr.2017.6873 [miArrest™ miR-504 inhibitor clone]
- D'Ippolito, E., and Plantamura, I. (2017). MiR-9 and miR-200 regulate PDGFR-mediated endothelial differentiation of tumor cells in triple negative breast cancer. BoMed Research International [miArrest™ miR-200c inhibitor clone]
- Wang, Y., et al. (2017). Long non-coding RNA CASC2 suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells through CASC2/miR-367/FBXW7 axis. Molecular Cancer DOI: 10.1186/s12943-017-0702-z [miExpress™ miR-367 inhibitor clone]
- Ji, C., et al. (2017). miR-93 enhances hepatocellular carcinoma invasion and metastasis by EMT via targeting PDCD4. Biotechnology Letters DOI: 10.1007/s10529-017-2403-5 [miArrest™ miR-93 inhibitor clone]
- Tang, T., et al. (2017). MicroRNA-212 functions as a tumor-suppressor in human non-small cell lung cancer by targeting SOX4. Oncology Reports DOI: 10.3892/or.2017.5885 [miArest™ miR-212 inhibitor clone]
- Ji, H.P., et al. (2017). MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors. Scientific Reports DOI: 10.1038/s41598-017-11112-4 [miArrest™ miRNA inhibitor clones]
- Tao, Y., et al. (2017). miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells. Biomedicine and Pharmacotherapy DOI: 10.1016/j.biopha.2017.09.147 [miArrest™ miR-205 inhibitor clone]
- Avigad, S., et al. (2017). PROGNOSTIC METHODS AND SYSTEMS OF TREATMENT FOR ACUTE LYMPHOBLASTIC LEUKEMIA. [miArrest™ miR-451 inhibitor clone]
- Li, L., et al. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death & Disease DOI: 10.1038/cddis.2017.497. [miArrest™ miR-295 inhibitor clone]
- Valera, E. et al. (2017). MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy. Frontiers in Molecular Neuroscience DOI: 10.3389/fnmol.2017.00329 [miArrest™ miR-101a inhibitor clone]
- Chang, W., et al. (2017). Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance. Oncology Reports DOI: 10.3892/or.2017.6046 [miArrest™ miR-134 inhibitor clone]
- Tao, Y., et al. (2017). MicroRNA-216a inhibits the metastasis of gastric cancer cells by targeting JAK2/STAT3-mediated EMT process. Oncotarget DOI: 10.18632/oncotarget.21488 [miArrest™ miR-216a inhibitor clone]
- Wang, J., et al. (2017). miR-365 promotes diabetic retinopathy through inhibiting Timp3 and increasing oxidative stress. Experimental Eye Research DOI: 10.1016/j.exer.2017.11.006 [miArrest™ miR-355 inhibitor clone]
- Gu, C., et al. (2017). MicroRNA-212 inhibits the proliferation, migration and invasion of renal cell carcinoma by targeting X-linked inhibitor of apoptosis protein (XIAP). Oncotarget DOI: 10.18632/oncotarget.20786 [miArrest™ miR-212 inhibitor clone]
- Du, B., et al. (2017). MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14. Biomedicine and Pharmacotherapy DOI: 10.1016/j.biopha.2017.11.090 [miArrest™ miR-1202 inhibitor clone]
- Yu, Z., et al. (2017). microRNA-196b promotes cell migration and invasion by targeting FOXP2 in hepatocellular carcinoma. Oncology Reports DOI: 10.3892/or.2017.6130 [miArrest™ miR-196b inhibitor clone]
- Tang, W., et al. (2017). miR302a-3p May Modulate Renal Epithelial-Mesenchymal Transition in Diabetic Kidney Disease by Targeting ZEB1. Nephron DOI: 10.1159/000481465 [miArrest™ miR-302a-3p inhibitor clone]
- Li, K-P., et al. (2017). Upregulation of miR-598 promotes cell proliferation and cell cycle progression in human colorectal carcinoma by suppressing INPP5E expression. Molecular Medicine Reports DOI: 10.3892/mmr.2017.8207 [miArrest™ miR-598 inhibitor clone]
- Li, C., et al. (2017).MicroRNA-1271 functions as a metastasis and epithelial-mesenchymal transition inhibitor in human HCC by targeting the PTP4A1/c-Src axis. International Journal of Oncology DOI: 10.3892/ijo.2017.4224 [miArrest™ miR-1271 inhibitor clone]
- Zhang, G., et al. (2017). Long non-coding RNA HNF1A-AS1 promotes cell proliferation and invasion via regulating miR-17-5p in non-small cell lung cancer. Biomedicine and Pharmacotherapy DOI: 10.1016/j.biopha.2017.12.080 [miArrest™ miR-17-5p inhibitor clone]
- Gill, P., et al. (2017). MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. Scientific Reports DOI: 10.1038/s41598-017-11811-y [miArrest™ miR-122 inhibitor clone]
<2016
- Zhao, N. et al. (2016) miR-27a-3p suppresses tumor metastasis and VM by down-regulating VE-cadherin expression and inhibiting EMT: an essential role for Twist-1 in HCC. Scientific Reports,DOI: 10.1038/srep23091. [miR-27a-3p Inhibitor (HmiR-AN0359-AM02), CmiR-AN0001-AM02)]
- Wang, Y. et al. (2016) Regulation of proliferation, angiogenesis and apoptosis in hepatocellular carcinoma by miR-26b-5p. Tumor Biology,DOI:10.1007/s13277-016-4964-7. [miR-26b- 5p-inhibitor and the corresponding empty vector plasmids]
- Jeyabal, P. et al. (2016) MicroRNA-9 inhibits hyperglycemia induced cardiac pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1. Biochemical and Biophysical Research Communications,Volume 471, Issue 4, 18 March 2016, Pages 423–429. [control or miR-9 mimic or miR-9 inhibitor and ELAVL1 target clone (HmiT004694-a) in pEZX-ELAVL1-UTR]
- Mo, X. et al. (2016) MicroRNA-610 suppresses the proliferation of human glioblastoma cells by repressing CCND2 and AKT3.Molecular Medicine Reports,Pages: 1961-1966 DOI: 10.3892/mmr.2016.4760. [miR-610 mimics, negative control, and miR-610 inhibitor]
- Wu, AH. et al. (2016) MiR-572 prompted cell proliferation of human ovarian cancer cells by suppressing PPP2R2C expression.Biomedicine & Pharmacotherapy,Volume 77, February 2016, Pages 92–97. [miR-572 mimic, miR-572 inhibitor, the relative negative controls and small interfering RNA-PPP2R2C (PPP2R2C-siRNA#1, HSH014202; PPP2R2C-siRNA#2, HSH014203)]
- Li , T. et al. (2016) MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer. Journal of Experimental & Clinical Cancer Research,DOI: 10.1186/s13046-016-0287-1. [The miR-224 mimics, negative control and anti-miR-224 inhibitors]
- Yang, H., et al. (2016). Over-expression of microRNA-940 promotes cell proliferation by targeting GSK3β and sFRP1 in human pancreatic carcinoma. Biomedicine & Paharmacotherapy DOI: 10.1016/j.biopha.2016.06.057 [mir-940 mimics and anti-miR-940 inhibitor clones]
- Deng, J., et al. (2016). miR-493 contributes to the proliferation and cell cycle in prostate cancer cells by repressing PHLPP2. Int J Clin Exp Pathol 9, 15728 [mir-493 mimics and anti-miR-493 inhibitor clones]
- Qin, L., et al. (2016). MicroRNA-455 regulates migration and invasion of human hepatocellular carcinoma by targeting Runx2. Oncology Reports DOI: 10.3892/or.2016.5139 [miArrest™ human miRNA-455 inhibtor clone and control clone]
- Geekiyanage, H., and Galanis, E. (2016). MiR-31 and miR-128 regulates poliovirus receptor-related 4 mediated measles virus infectivity in tumors. Molecular Oncology DOI: 10.1016/j.molonc.2016.07.007 [miArrest™ MiR-31 and miR-128 inhibitor clones]
- Dou, C., et al. (2016). miR-187-3p inhibits the metastasis and epithelial–mesenchymal transition of hepatocellular carcinoma by targeting S100A4. Cancer Letters DOI: 10.1016/j.canlet.2016.08.011 [miArrest™ miR-187-3p inhibitor clone]
- Chen, B., et al. (2016). miR-22 contributes to the pathogenesis of patients with coronary artery disease by targeting MCP-1: An observational study. Medicine DOI: 10.1097/MD.0000000000004418 [miArrest™ miR-22 inhibitor clone]
- Yang, X., et al. (2016). MicroRNA-133b inhibits the migration and invasion of non small cell lung cancer cells via targeting FSCN1. Oncology Letters DOI: 10.3892/ol.2016.5044 [miArrest™ miR-133b inhibitor clone]
- Qiu, H., et al. (2016). miR-186 suppressed CYLD expression and promoted cell proliferation in human melanoma. Oncology Letters DOI: 10.3892/ol.2016.5002 [miArrest™ miR-186 inhibitor clone]
- Li, Y., et al. (2016). MicroRNA-520c enhances cell proliferation, migration and invasion by suppressing IRF2 in gastric cancer. FEBS Open Bio DOI: 10.1002/2211-5463.12142 [miArrest™ miR-520c miRNA inhibitor clone]
- Wang, F., et al. (2016). microRNA-590 suppresses the tumorigenesis and invasiveness of non-small cell lung cancer cells by targeting ADAM9. Molecular and Cellular Biochemistry DOI: 10.1007/s11010-016-2822-y [miArrest™ miR-590 miRNA inhibitor]
- Kang, M., et al. (2016). A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells. Oncotarget DOI: 10.18632/oncotarget.8811 [miArrest™ miR-200c, mir-144 miRNA inhibitor clones]
- Zhang, D., et al. (2016). miR-155 regulates high glucose-induced cardiac fibrosis via the TGF-β signaling pathway. Molecular Biosystems DOI: 10.1039/C6MB00649C [miR-155 hairpin inhibitor]
- Chen, A., et al. (2016). MICRO-RNAS AND COMPOSITIONS COMPRISING SAME FOR THE TREATMENT AND DIAGNOSIS OF SEROTONIN-, ADRENALIN-, NORADRENALIN-, GLUTAMATE-, AND CORTICOTROPIN-RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONSNORADREANLIN-, GLUTAMATE-, AND CORTICOTROPIN RELEASING HORMONE- ASSOCIATED MEDICAL CONDITIONS. United States Patent Application 20160348101 [miArrest™ miR-19, miR-19b, miR-135b, miR-182 miRNA inhibitor clones]
<2015
- Wang S, et al (2015) MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction.Molecular Medicine Reports,Pages: 273-280 DOI: 10.3892/mmr.2015.4557. [the pre-miR-1246, pre-con, anti-1246 or anti-con]
- Jamshidi, F. et al. (2015) The genomic landscape of epithelioid sarcoma cell lines and tumors. The Journal of Pathology,DOI: 10.1002/path.4636. [Human lentiviral miRNA inhibitor vectors]
- Chi, H. et al. (2015) miR-194 regulated AGK and inhibited cell proliferation of oral squamous cell carcinoma by reducing PI3K-Akt-FoxO3a signaling. Biomedicine & Pharmacotherapy,Volume 71, April 2015, Pages 53–57. [miR-194 mimic, miR-194 inhibitor and negative control]
- Li, X. et al. (2015) MicroRNA-125b is involved in atherosclerosis obliterans in vitro by targeting podocalyxin. Molecular Medicine Reports,Pages: 561-568 DOI: 10.3892/mmr.2015.3384. [miR-125b mimics, pre- and anti-scramble controls]
- Ge, S. et al. (2015) MicroRNA‐19b reduces hepatic stellate cell proliferation by targeting GRB2 in hepatic fibrosis models in vivo and in vitro as part of the inhibitory effect of estradiol. Journal of Cellular Biochemistry,DOI: 10.1002/jcb.25116. [miRNA inhibitor]
- Zhang, Z. et al. (2015) Microrna-153 acts as a prognostic marker in gastric cancer and its role in cell migration and invasion.OncoTargets and Therapy,OncoTargets and Therapy 2015:8 357–364. [miR-153, HmiR0039-MR04, CmiR0001- MR04, HmiR-AN0214-AM04,CmiR-AN0001- AM04]
- Zhang, S. et al. (2015) MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.Biomedicine & Pharmacotherapy,Volume 70, Issue null, Pages 164-169. [miR-522 mimics, negative control, miR-522 inhibitor and miR-522-mut]
- Xia, K. et al. (2015) miR-411 regulated ITCH expression and promoted cell proliferation in human hepatocellular carcinoma cells.Biomedicine & Pharmacotherapy,Volume 70, Issue null, Pages 158-163. [miR-411 mimics, negative control, miR-411 inhibitor and miR-411-mut]
- Xu, Z. et al. (2015) Isorhapontigenin suppresses growth of patient-derived glioblastoma spheres through regulating miR-145/SOX2/cyclin D1 axis. Neuro-Oncology,Neuro Oncol. 2015 Dec 17. pii: nov298. [miR-145 inhibitor]
- Kondo, H. et al. (2015) Blockade of senescence‐associated microRNA‐195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells.. Aging Cell,DOI: 10.1111/acel.12411. [a lentiviral vector expressing inhibitor for miR-195 and a scrambled control vector]
- Bai, Y. et al. (2015) MiR-615 inhibited cell proliferation and cell cycle of human breast cancer cells by suppressing of AKT2 expression. International Journal of Clinical and Experimental Medicine,Int J Clin Exp Med. 2015; 8(3): 3801–3808.. [MiR-615 mimic, miR-615 inhibitor, miR-615-mut and negative control]
- He, W. et al. (2015) MiR-374a promotes the proliferation of human osteosarcoma by downregulating FOXO1 expression.International Journal of Clinical and Experimental Medicine,Int J Clin Exp Med. 2015; 8(3): 3482–3489.. [MiR-374a mimic, miR-374a inhibitor and negative control]
- Qiu, M. et al. (2015) MicroRNA-429 suppresses cell proliferation, epithelial-mesenchymal transition, and metastasis by direct targeting of BMI1 and E2F3 in renal cell carcinoma. Urologic Oncology: Seminars and Original Investigations,DOI:10.1016/j.urolonc.2015.03.016. [DNA fragments encoding miR-429, control miRNA, miR-429 inhibitor, and inhibitor control siRNAs into pEZX-MR03 plasmid]
- Liu, YN. et al. (2015) Loss of Androgen Regulated miR-1 Activates SRC and Promotes Prostate Cancer Bone Metastasis. Molecular and cellular biology,DOI: 10.1128/MCB.00008-15. [anti-miR 335 inhibitor]
- Zhuo , W. et al. (2015) MicroRNA-20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing early growth response 2 expression. Molecular Medicine Reports,Pages: 4989-4994 DOI: 10.3892/mmr.2015.4098. [miR-20a mimic, miR-20a inhibitor and negative control (NC)]
- Hong , Z. et al. (2015) miR-106a Is Downregulated in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B and Associated with Enhanced Levels of Interleukin-8. Mediators of Inflammation,http://dx.doi.org/10.1155/2015/629862. [hsa-miR-106a mimics, hsa-miR-106a inhibitor]
- Long , J. et al. (2015) MiR-503 inhibited cell proliferation of human breast cancer cells by suppressing CCND1 expression. Tumor Biology, DOI:10.1007/s13277-015-3623-8. [MiR-503 mimic, miR-503 inhibitor, and negative control]
- Liu , Y. et al. (2015) MiR-214 suppressed ovarian cancer and negatively regulated semaphorin 4D. Tumor Biology, DOI:10.1007/s13277-015-4708-0. [miRNA mimic and inhibitor for hsa-miR-214-5p, mimic and inhibitor negative controls]
- Hong , Z. et al. (2015) miR-106a is downregulated in peripheral blood mononuclear cells of Chronic. Mediators of Inflammation,Volume 2015 (2015), Article ID 629862, 9 pages. [hsa-miR-106a mimics, hsa-miR-106a inhibitor, and controls]
- Zhao , D. et al. (2015) MicroRNA-203 inhibits the malignant progression of neuroblastoma by targeting Sam68. Molecular Medicine Reports,Pages: 5554-5560 DOI: 10.3892/mmr.2015.4013. [miR-203 mimics and scramble miRNA]
- Liu , Y. et al. (2015) microRNA-124 targets Tip110 expression and regulates hematopoiesis. Stem Cells and Development,Development. August 2015, 24(17): 2009-2017. DOI:10.1089/scd.2015.0030. [miR-124 (HmiR0427-MR03) and miR-124 inhibitor (HmiR-AN0074-AM03)]
- Zhang, X. et al. (2015) PARN deadenylase is involved in miRNA-dependent degradation of TP53 mRNA in mammalian cells. Nucleic Acids Research,DOI: 10.1093/nar/gkv959. [miR-125b inhibitor expression plasmid (HmiR-AN0096-AM03), control plasmid (AM03)]
<2014
- Kan , H. et al. (2014) MicroRNA-520g induces epithelial–mesenchymal transition and promotes metastasis of hepatocellular carcinoma by targeting SMAD7. FEBS Letters, DOI: 10.1016/j.febslet.2014.11.031. [miR-520g expression vector (HmiR0334-MR04), the control vector for miR-520g (CmiR0001-MR04), miR-520g inhibitor (HmiR-AN0603-AM04) and the negative control for the miR-520g inhibitor (CmiR-AN0001-AM04)]
- Tu, K. et al. (2014) MicroRNA-130b Promotes Cell Aggressiveness by Inhibiting Peroxisome Proliferator-Activated Receptor Gamma in Human Hepatocellular Carcinoma. International Journal of Molecular Sciences,DOI:10.3390/ijms151120486. [miR-130b inhibitor]
- Shen , F. et al. (2014) MiR-492 contributes to cell proliferation and cell cycle of human breast cancer cells by suppressing SOX7 expression. Tumor Biology,Volume 36, Issue 3, pp 1913-1921. [MiR-492 mimic, miR-492 inhibitor, miR-492-mut, and nega- tive control]
- Hung, TM. et al. (2014) Up-Regulation of MicroRNA-190b Plays a Role for Decreased IGF-1 That Induces Insulin Resistance in Human Hepatocellular Carcinoma. PLOS ONE, 2014 Feb 20;9(2):e89446. DOI: 10.1371/journal.pone.0089446. [pEZX-AM01]
- Li, J. et al. (2014) Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. Biochem Biophys Res Commun, 2014 Mar 28;446(1):267-71. DOI: 10.1016/j.bbrc.2014.02.096. [miR-146b-3p]
- Rago, L. et al. (2014) miR379–410 cluster miRNAs regulate neurogenesis and neuronal migration by fine‐tuning N‐cadherin. The EMBO Journal, 2014 Mar 5;9(3):e90629. DOI: 10.1371/journal.pone.0090629.. [anti-miRs locked nucleic acids]
- Hu, Y. et al. (2014) MiR-199a-5p Loss Up-Regulated DDR1 Aggravated Colorectal Cancer by Activating Epithelial-to-Mesenchymal Transition Related Signaling. Digestive Diseases and Sciences, DOI:10.1007/s10620-014-3136-0. [pre-miR-199a-5p, pre-con, anti-199a-5p]
- Leotta, M. et al. (2014) A p53‐dependent tumor suppressor network is induced by selective miR‐125a‐5p inhibition in multiple myeloma cells in vitro. Journal of Cell Physiology, 2014 May 13. DOI: 10.1002/jcp.24669. [miR-125a-5p]
- Tsubota, A. et al. (2014) Involvement of MAP3K8 and miR-17-5p in Poor Virologic Response to Interferon-Based Combination Therapy for Chronic Hepatitis C. PLOS ONE, 2014 May 12;9(5):e97078. DOI: 10.1371/journal.pone.0097078. [hsa-miR-17-5p]
- Brockhausen, J. et al. (2014) miR‐181a mediates TGF‐β induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer.. Liver International, DOI: 10.1111/liv.12517. . [pEZX-MR04 and pEZX-CR04]
- Yu, J. et al. (2014) Effect of miR-205 on 3T3-L1 preadipocyte differentiation through targeting to glycogen synthase kinase 3 beta. Biotechnology Letters, 2014 Jun;36(6):1233-43. DOI: 10.1007/s10529-014-1491-8. [pEZX-MR04]
- Bagashev, A. et al. (2014) Involvement of miR-196a in HIV-associated neurocognitive disorders. Apoptosis, Apoptosis. 2014 Aug;19(8):1202-14. DOI: 10.1007/s10495-014-1003-2. [miR-30a and miR-196a]
- Yang, F. et al. (2014) A Novel Berbamne Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and …. PLOS ONE, 2014 Jun 18;9(6):e100708. DOI: 10.1371/journal.pone.0100708. [hsa-miRNA-4284 and has-miRNA-27a]
- Hanin, G. et al . (2014) Competing targets of microRNA-608 affect anxiety and hypertension. Human Molecular Genetics, DOI: 10.1093/hmg/ddu170. [pre-miR-132, -608]
- Tapocik, JD. et al. (2014) microRNA-206 in Rat Medial Prefrontal Cortex Regulates BDNF Expression and Alcohol Drinking. The Journal of Neuroscience, 2014 Mar 26;34(13):4581-8. DOI: 10.1523/JNEUROSCI.0445-14.2014. [miR-206]
- Kohno, T. et al. (2014) Human microRNA hsa‐miR‐1231 suppresses hepatitis B virus replication by targeting core mRNA. Journal of Viral Hepatitis, 2014 May 16. DOI: 10.1111/jvh.12240. [CmiR0001-MR01]
- Duan, P. et al. (2014) miR-29a Modulates Neuronal Differentiation through Targeting REST in Mesenchymal Stem Cells. PLOS ONE, 2014 May 19;9(5):e97684. DOI: 10.1371/journal.pone.0097684. [miR-29a precursor (RmiR6139-MR03)]
- Lin, Y. et al. (2014) KSRP and MiR-145 Are Negative Regulators of Lipolysis in White Adipose Tissue. Molecular and Cellular, Mol Cell Biol. 2014 Jun 15;34(12):2339-2349. [pEZX-MT01]
- Lee, S. et al. (2014) microRNA-495 Inhibits Chondrogenic Differentiation in Human Mesenchymal Stem Cells by Targeting Sox9 . Stem Cells and Development, DOI:10.1089/scd.2013.0609.. [pEZX-SOX9 3′UTR and pEZX-MT01]
- Wagh, V. et al. (2014) MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes. Stem Cell Res Ther, DOI:10.1186/scrt464. [pEZX-MT01]
- Qadir, XV. et al. (2014) MicroRNA-185 Inhibits Hepatocellular Carcinoma Growth by Targeting the DNMT1/PTEN/Akt Pathway. The American Journal of Pathology, 2014 Jun 6. pii: S0002-9440(14)00275-2. DOI: 10.1016/j.ajpath.2014.05.004. [miR-185 (L/miR-185)]
- Ayyadurai, S. et al. (2014) Colonic miRNA Expression/Secretion, Regulated by Intestinal Epithelial PepT1, Plays an Important Role in Cell-to-Cell Communication during Colitis. PLOS ONE, 2014 Feb 19;9(2):e87614. DOI: 10.1371/journal.pone.0087614. [Luc-Marcksl-1 3′UTR]
- Hupkes, M. et al. (2014) MicroRNA miR-378 promotes BMP2-induced osteogenic differentiation of mesenchymal progenitor cells. BMC Molecular Biology , BMC Molecular Biology 2014, 15:1 DOI:10.1186/1471-2199-15-1. [Grem1, Wnt5a or Wnt10a UTR pEZX-MT01 vector & Luciferase Assay Kit]
- Floyd, DH. et al. (2014) Novel Anti-Apoptotic MicroRNAs 582-5p and 363 Promote Human Glioblastoma Stem Cell Survival via Direct Inhibition of Caspase 3, Caspase 9, and Bim. PLOS ONE, 2014 May 7;9(5):e96239. DOI: 10.1371/journal.pone.0096239. [miRNA 3'UTR (FosBcl2l11)]
- Tripathi, AK. et al. (2014) Attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro. Journal of Biomedical, J Biomed Sci. 2014 May 7;21(1):39. DOI: 10.1186/1423-0127-21-39. [wild-type 3′UTR with the miR-203 binding site of c-Jun]
- Stevanato, L. et al. (2014) The effects of microRNAs on human neural stem cell differentiation in two-and three-dimensional cultures. Stem Cell Research & Therapy, DOI:10.1186/scrt437. [MicroRNA 3′ UTR Target Clone HmiT019538-MT01 ( NR4A3 3′ UTR)]
- Kurtz, CL. et al. (2014) microRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. Diabetes, DOI:10.2337/db13-1015. [3' UTR of HMGCS2]
- Sarma, NJ. et al. (2014) Hepatitis C Virus-Induced Changes in MicroRNA 107 (miRNA-107) and miRNA-449a Modulate CCL2 by Targeting the Interleukin-6 Receptor Complex in Hepatitis. Journal of Virology, DOI: 10.1128/JVI.03060-13. [IL-6R (HmiT009673-MT01) and JAK1 (HmiT009849-MT01)]
- Zhang, Y. et al. (2014) MicroRNA-608 and MicroRNA-34a Regulate Chordoma Malignancy by Targeting EGFR, Bcl-xL and MET. PLOS ONE, 2014 Mar 12;9(3):e91546. DOI: 10.1371/journal.pone.0091546.. [Bcl-xL 3′UTR-Luc]
- Clay, CC. et al. (2014) Early Life Ozone Exposure Results in Dysregulated Innate Immune Function and Altered microRNA Expression in Airway Epithelium. PLOS ONE, 2014 Mar 4;9(3):e90401. DOI: 10.1371/journal.pone.0090401. [3′ UTR IL-6]
- Osbourne, A. et al. (2014) Downregulation of Connexin43 by MicroRNA-130a in Cardiomyocytes Results in Cardiac Arrhythmias. Journal of Moleclular and Cellular Cardiology, 2014 May 10;74C:53-63. DOI: 10.1016/j.yjmcc.2014.04.024. [Cx43 3'UTR reporter]
<2013
- Liao, WT, et al (2013) MicroRNA‐30b functions as a tumour suppressor in human colorectal cancer by targeting KRAS, PIK3CD and BCL2. The Journal of Pathology, DOI: 10.1002/path.4309. [miR-30b mimics, negative control and anti-miR-30b inhibitors].
- Sun, X. et al (2013) HspB1 silences translation of PDZ-RhoGEF by enhancing miR-20a and miR-128 expression to promote neurite extension. Molecular and Cellular Neuroscience, Volume 57, November 2013, Pages 111–119. [miArrest™ MicroRNA Inhibitors for miR-20a, miR-128 and miR-132].
- Dimri, M. et al (2013) microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts. Cell Cycle, Volume 12, Issue 22, Pages 3537-3546. [pEZX-AM03 expressing hsa-miR-141 inhibitor, pEZX-MR03 expressing either hsa-miR-141 or hsa-miR-200c].
- Liao, WT. et al (2013) MicroRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2. Clinical Cancer Research, Clin Cancer Res September 1, 2013 19; 4662. [miR-224 mimics, negative control, and anti-miR-224 inhibitors].
- Nguyen, T. et al (2013) MiR-24 Promotes the Survival of Hematopoietic Cells. PloS one, 8(1): e55406. DOI:10.1371/journal.pone.0055406. [miR-24 miRNA inhibitor].
< 2012
- Sharma, S. et al. (2012) Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy. EMBO Molecular Medicine, Volume 4, Issue 7, pages 617–632, July 2012. [miR142-5p inhibitor].
- Kong, Y. et al. (2012) The Deoxycholic Acid Targets miRNA-dependent CAC1 Gene Expression in Multidrug Resistance of Human Colorectal Cancer. The International Journal of Biochemistry & Cell Biology, Available online 10 August 2012. [miR-199a-5p].
- Samakoglu, S. et al. (2012) Preclinical Rationale for Combining an EGFR Antibody with Cis... Cancer Genomics and Proteomics March-April 2012 vol. 9 no. 2 77-92. [hsa-miRNA-29b synthetic inhibitor].
- Izumiya, M. et al. (2011) Systematic exploration of cancer-associated microRNA through functional screening assays. Cancer Science Volume 102, Issue 9. [miRNA inhibitor and precursor miRNA].