产品介绍
MicroRNA ( miRNA )是真核细胞转录形成的非编码单链小分子RNA。它们的序列高度保守，通常是21到23个核苷酸长度，几乎与所有的细胞功能和基因表达调控有关。它们通过靶定到mRNA 3’非翻译区（3′ UTR）来调节基因的表达。MicroRNA靶标基因的表达失调与癌症、 心血管疾病等各种疾病的发生有关。
GeneCopoeia提供eGFP作为报告基因的miExpress™ miRNA前体表达克隆，将miRNA的茎环前体（约150核苷酸）克隆到病毒和非病毒载体可以感染几乎所有细胞。
优势
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覆盖面广
灵活的载体选择
优化的表达框
可选标记和报告基因
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| 图1. miRNA前体表达克隆和miRNA 3′ UTR克隆在miRNA调控过程中的作用机理 |
载体
miRNA前体表达克隆载体 |
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载体
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示踪基因
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筛选标记
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启动子
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病毒类型
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| pEZX-MR03 | eGFP | Puromycin | CMV | HIV |
| pEZX-MR04 | eGFP | Puromycin | CMV | Mammalian |
miRNA前体表达AAV载体 |
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载体
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示踪基因
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筛选标记
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启动子
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病毒类型
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| pEZX-MR14 | eGFP | Puromycin | CMV | AAV |
| pEZX-MR15 | mCherry | Puromycin | CMV | AAV |
慢病毒载体的miRNA前体表达克隆
GeneCopoeia提供客户定制的慢病毒载体miRNA前体表达克隆，周期为2-5周。
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克隆套装
前体miRNA克隆套装
GeneCopoeia除了提供单个克隆，还提供预制和定制的前体miRNA克隆套装。了解详情请点击联系我们或拨打4006-020-200。
| 载体 | 载体类型 | 启动子 | 筛选标记 | Tag |
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| pEZX-MR03 | Mammalian expression (lentiviral) | CMV | Puromycin | eGFP |
| pEZX-MR04 | Mammalian expression | CMV | Puromycin | eGFP |
如果您有什么问题，请致电4006-020-200，或发邮件至sales@igenebio.com。
| 载体： | 套装类型 ： |
| 货号 | 旧货号 | 物种 | 套装类型 | 产品 | 相关疾病 | miRNA | 载体 | 价格 |
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| MPC-MF001-MR03 | MPC-HG-MR03 | Human | Whole genome | Human whole genome miRNA precursor clone set (lentiviral) | 1971 | pEZX-MR03 |
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| MPC-MF004-MR03 | MPC-HCA-MR03 | Human | Cancer | Human Pituitary Adenoma miRNA Precursor Clone Set (lentiviral) | Pituitary Adenoma | 27 | pEZX-MR03 |
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| MPC-MF005-MR03 | MPC-HCB-MR03 | Human | Cancer | Human Breast Cancer miRNA Precursor Clone Set (lentiviral) | Breast Cancer | 144 | pEZX-MR03 |
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| MPC-MF006-MR03 | MPC-HCC-MR03 | Human | Cancer | Human Colorectal Cancer miRNA Precursor Clone Set (lentiviral) | Colorectal Cancer | 141 | pEZX-MR03 |
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| MPC-MF007-MR03 | MPC-HCE-MR03 | Human | Cancer | Human Mesothelioma miRNA Precursor Clone Set (lentiviral) | Mesothelioma | 20 | pEZX-MR03 |
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| MPC-MF008-MR03 | MPC-HCG-MR03 | Human | Cancer | Human Gastric Cancer miRNA Precursor Clone Set (lentiviral) | Gastric Cancer | 60 | pEZX-MR03 |
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| MPC-MF009-MR03 | MPC-HCH-MR03 | Human | Cancer | Human Hepatocellular Carcinoma miRNA Precursor Clone Set (lentiviral) | Hepatocellular Carcinoma | 130 | pEZX-MR03 |
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| MPC-MF010-MR03 | MPC-HCI-MR03 | Human | Cancer | Human Cholangiocarcinoma miRNA Precursor Clone Set (lentiviral) | Cholangiocarcinoma | 26 | pEZX-MR03 |
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| MPC-MF011-MR03 | MPC-HCJ-MR03 | Human | Cancer | Human Thyroid Carcinoma miRNA Precursor Clone Set (lentiviral) | Thyroid Carcinoma | 40 | pEZX-MR03 |
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| MPC-MF012-MR03 | MPC-HCK-MR03 | Human | Cancer | Human Kidney Cancer miRNA Precursor Clone Set (lentiviral) | Kidney Cancer | 61 | pEZX-MR03 |
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| MPC-MF013-MR03 | MPC-HCL-MR03 | Human | Cancer | Human Lung Cancer miRNA Precursor Clone Set (lentiviral) | Lung Cancer | 134 | pEZX-MR03 |
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| MPC-MF014-MR03 | MPC-HCM-MR03 | Human | Cancer | Human Melanoma miRNA Precursor Clone Set (lentiviral) | Melanoma | 103 | pEZX-MR03 |
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| MPC-MF015-MR03 | MPC-HCN-MR03 | Human | Cancer | Human Brain Cancer miRNA Precursor Clone Set (lentiviral) | Brain Cancer | 174 | pEZX-MR03 |
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| MPC-MF016-MR03 | MPC-HCO-MR03 | Human | Cancer | Human Ovarian Cancer miRNA Precursor Clone Set (lentiviral) | Ovarian Cancer | 138 | pEZX-MR03 |
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| MPC-MF017-MR03 | MPC-HCP-MR03 | Human | Cancer | Human Pancreatic Cancer miRNA Precursor Clone Set (lentiviral) | Pancreatic Cancer | 154 | pEZX-MR03 |
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| MPC-MF018-MR03 | MPC-HCQ-MR03 | Human | Cancer | Human Prostate Cancer miRNA Precursor Clone Set (lentiviral) | Prostate Cancer | 120 | pEZX-MR03 |
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| MPC-MF019-MR03 | MPC-HCR-MR03 | Human | Cancer | Human Myeloma miRNA Precursor Clone Set (lentiviral) | Myeloma | 38 | pEZX-MR03 |
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| MPC-MF020-MR03 | MPC-HCS-MR03 | Human | Cancer | Human Sarcoma miRNA Precursor Clone Set (lentiviral) | Sarcoma | 22 | pEZX-MR03 |
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| MPC-MF021-MR03 | MPC-HCT-MR03 | Human | Cancer | Human Head and Neck Cancer miRNA Precursor Clone Set (lentiviral) | Head and Neck Cancer | 141 | pEZX-MR03 |
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| MPC-MF022-MR03 | MPC-HCU-MR03 | Human | Cancer | Human Uterine Leiomyoma miRNA Precursor Clone Set (lentiviral) | Uterine Leiomyoma | 30 | pEZX-MR03 |
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| MPC-MF023-MR03 | MPC-HCV-MR03 | Human | Cancer | Human Cervical Cancer miRNA Precursor Clone Set (lentiviral) | Cervical Cancer | 21 | pEZX-MR03 |
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| MPC-MF024-MR03 | MPC-HCW-MR03 | Human | Cancer | Human Endometrial Cancer miRNA Precursor Clone Set (lentiviral) | Endometrial Cancer | 72 | pEZX-MR03 |
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| MPC-MF025-MR03 | MPC-HCX-MR03 | Human | Cancer | Human Leukemia miRNA Precursor Clone Set (lentiviral) | Leukemia | 126 | pEZX-MR03 |
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| MPC-MF026-MR03 | MPC-HCY-MR03 | Human | Cancer | Human Bladder Cancer miRNA Precursor Clone Set (lentiviral) | Bladder Cancer | 56 | pEZX-MR03 |
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| MPC-MF027-MR03 | MPC-HCZ-MR03 | Human | Cancer | Human Lymphoma miRNA Precursor Clone Set (lentiviral) | Lymphoma | 80 | pEZX-MR03 |
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| MPC-MF028-MR03 NEW! |
Human | Nervous system diseases | Human Alzheimer's disease miRNA Precursor Clone Set (lentiviral) | Alzheimer's disease | 540 | pEZX-MR03 |
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| MPC-MF029-MR03 NEW! |
Human | Nervous system diseases | Human Parkinson's disease miRNA Precursor Clone Set (lentiviral) | Parkinson's disease | 271 | pEZX-MR03 |
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| MPC-MF030-MR03 NEW! |
Human | Nervous system diseases | Human Huntington's disease miRNA Precursor Clone Set (lentiviral) | Huntington's disease | 19 | pEZX-MR03 |
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| MPC-MF031-MR03 NEW! |
Human | Nervous system diseases | Human Cerebral stroke miRNA Precursor Clone Set (lentiviral) | Cerebral stroke | 370 | pEZX-MR03 |
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| MPC-MF032-MR03 NEW! |
Human | Nervous system diseases | Human Epilepsy miRNA Precursor Clone Set (lentiviral) | Epilepsy | 110 | pEZX-MR03 |
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| MPC-MF033-MR03 NEW! |
Human | Nervous system diseases | Human Depression miRNA Precursor Clone Set (lentiviral) | Depression | 131 | pEZX-MR03 |
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| MPC-MF034-MR03 NEW! |
Human | Nervous system diseases | Human Schizophrenia miRNA Precursor Clone Set (lentiviral) | Schizophrenia | 102 | pEZX-MR03 |
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| MPC-MF035-MR03 NEW! |
Human | Programmed cell death | Human Ferroptosis miRNA Precursor Clone Set (lentiviral) | Programmed cell death | 39 | pEZX-MR03 |
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| MPC-MF036-MR03 NEW! |
Human | Programmed cell death | Human Autophagy miRNA Precursor Clone Set (lentiviral) | Programmed cell death | 198 | pEZX-MR03 |
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| MPC-MF037-MR03 NEW! |
Human | Programmed cell death | Human Pyroptosis miRNA Precursor Clone Set (lentiviral) | Programmed cell death | 36 | pEZX-MR03 |
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| MPC-MF038-MR03 NEW! |
Human | Programmed cell death | Human Apoptosis miRNA Precursor Clone Set (lentiviral) | Programmed cell death | 62 | pEZX-MR03 |
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| Custom order | Various | Custom-selected | Various | Custom-selected | Inquire |
相关产品
Citations
- ThanhLoan Tran, et, al (2026). The miR-2110/TRAF3 axis is associated with endothelial dysfunction and atherosclerosis in coronary heart disease. Biochemistry and Biophysics Reports DOI: 10.1016/j.bbrep.2026.102508 [miArrest™ Precursor miRNA hsa-mir-2110 and scrambled control, Cat. No. HmiR0720-MR03, CmiR0001-MR03; Lenti-Pac™ HIV Packaging Kit, Cat. No. LT002]
- Johan Guthormsen, et, al (2025). Cardiomyocyte overexpression of microRNA-210 mitigates apoptotic cell death induced by doxorubicin. Cardio-oncology DOI: 10.1186/s40959-025-00429-z [miExpress™ hsa-mir-210 precursor clone, Cat. No. HmiR0167-MR04; miArrest™ miRNA inhibitors against hsa-miR-210-3p, Cat. No. HmiR-AN0317-AM01; miRNA scrambled control clone for pEZX-MR04, Cat. No. CmiR0001-MR04; miRNA inhibitor scrambled control clone for pEZX-AM01, Cat. No. CmiR-AN0001-AM01]
- Mustafa Kotmakci, et, al (2025). Plasmid DNA Delivery to Cancer Cells with Poly(L-lysine)-Based Copolymers Bearing Thermally Sensitive Segments: Balancing Polyplex Tightness; Transfection Efficiency; and Biocompatibility. Pharmaceutics DOI: 10.3390/pharmaceutics17081012 [miTarget™ Precursor miRNA scrambled control for pEZX-MR04, Cat No. CmiR0001-MR04]
- Jeongmin Lee, et, al (2025). Differential expression and regulation of FASLG by miR-5195/miR-3941 in age-related hearing loss. PLOS One DOI: 10.1371/journal.pone.0331661 [miTarget™ Precursor miRNA clones for pEZX-MR04, Cat No. HmiR1468-MR04, Cat. No. HmiR1052-MR04]
- Tania Valencia, et, al (2025). The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity. Nature Communications DOI: 10.1038/s41467-025-65799-5 [miExpress™ HmiR0199, HmiR0202, HmiR0110, HmiR0392 Precursor miRNA clones in lentiviral and non-viral vectors]
