简介
激酶（Kinases）是催化磷酸基团从高能含磷分子（如ATP）向底物转移的酶，最大的激酶族群是蛋白激酶。激酶通过磷酸化其各自的下游特定底物蛋白来发挥其作用。它们催化从ATP或GTP的γ-磷酸转运到底物蛋白中丝氨酸，苏氨酸和酪氨酸的羟基或脂质中的糖基部分。包括：腺苷酸激酶AMPK、肌酸激酶CK、丙酮酸激酶PK、己糖激酶HK、核苷二磷酸激酶NDPKs、胸苷激酶TK1/TK2等。激酶失调可导致酶活性和/或酶表达、亚细胞定位、激酶稳定性、蛋白质-蛋白质相互作用等的变化。激酶介导的信号传导途径的异常调节是造成所有主要人类病理状况的原因，例如癌症、心血管疾病、神经退行性疾病和代谢紊乱。
套装信息
| 新货号 | 旧货号 | 物种 | 基因数 | 载体 | 载体类型 | 价格 |
|---|---|---|---|---|---|---|
| OC-GF013-M02 | OC-HKI-M02 | Human | 666 | pReceiver-M02 | Expression-ready Non-viral | Inquire |
| OC-GF013-M35 | OC-HKI-M35 | Human | 666 | pReceiver-M35 | Expression-ready Non-viral | Inquire |
| OC-GF013-M98 | OC-HKI-M98 | Human | 666 | pReceiver-M98 | Expression-ready Non-viral | Inquire |
| OC-GF013-Lv105 | OC-HKI-Lv105 | Human | 666 | pReceiver-Lv105 | Expression-ready Lentiviral | Inquire |
| OC-GF013-Lv242 | OC-HKI-Lv242 | Human | 666 | pReceiver-Lv242 | Expression-ready Lentiviral | Inquire |
| OC-GF013-GC | OC-HKI-GC | Human | 666 | pDONR™ Vector | Gateway shuttle | Inquire |
克隆列表
表格仅包含克隆套装部分内容，如需更多信息请通过电话（4006-020-200）或邮件（sales@igenebio.com）联系我们。
| Symbol | NCBI注册号 | 物种 | 基因描述 | ORF length(bp) | 产品ID |
| CDKN1A | NM_001220778.2 | Human | Homo sapiens cyclin dependent kinase inhibitor 1A (CDKN1A), transcript variant 4, mRNA. | 495 | GC-G0313 |
| ABL2 | NM_005158.5 | Human | Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant c, mRNA. | 3504 | GC-Z1255 |
| CPNE3 | NM_003909.5 | Human | Homo sapiens copine 3 (CPNE3), mRNA. | 1614 | GC-S0040 |
| PACSIN1 | NM_001199583.3 | Human | Homo sapiens protein kinase C and casein kinase substrate in neurons 1 (PACSIN1), transcript variant 2, mRNA. | 1335 | GC-T4656 |
| STK40 | NM_032017.3 | Human | Homo sapiens serine/threonine kinase 40 (STK40), transcript variant 3, mRNA. | 1308 | GC-T8395 |
| NEK3 | NM_002498.3 | Human | Homo sapiens NIMA related kinase 3 (NEK3), transcript variant 1, mRNA. | 1521 | GC-T8423 |
| MAPKAP1 | NM_024117.4 | Human | Homo sapiens MAPK associated protein 1 (MAPKAP1), transcript variant 2, mRNA. | 1461 | GC-V0508 |
| CAMK1D | NM_153498.4 | Human | Homo sapiens calcium/calmodulin dependent protein kinase ID (CAMK1D), transcript variant 2, mRNA. | 1158 | GC-Y2805 |
| AKT1 | NM_005163.2 | Human | Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 1, mRNA. | 1443 | GC-A0022 |
| CDK2 | NM_001798.5 | Human | Homo sapiens cyclin dependent kinase 2 (CDK2), transcript variant 1, mRNA. | 897 | GC-A0035 |
| EPHA3 | NM_005233.6 | Human | Homo sapiens EPH receptor A3 (EPHA3), transcript variant 1, mRNA. | 2952 | GC-A0059 |
| TGFBR2 | NM_003242.6 | Human | Homo sapiens transforming growth factor beta receptor 2 (TGFBR2), transcript variant 2, mRNA. | 1704 | GC-A0063 |
| ACVR2A | NM_001616.5 | Human | Homo sapiens activin A receptor type 2A (ACVR2A), transcript variant 2, mRNA. | 1542 | GC-A0075 |
| EPHA2 | NM_004431.5 | Human | Homo sapiens EPH receptor A2 (EPHA2), transcript variant 1, mRNA. | 2931 | GC-A0125 |
| MAPK3 | NM_002746.3 | Human | Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 1, mRNA. | 1140 | GC-A0161 |
| FGFR4 | NM_213647.3 | Human | Homo sapiens fibroblast growth factor receptor 4 (FGFR4), transcript variant 3, mRNA. | 2409 | GC-A0196 |
| RPS6KA1 | NM_002953.3 | Human | Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 1, mRNA. | 2208 | GC-A0206 |
| PRKCD | NM_006254.4 | Human | Homo sapiens protein kinase C delta (PRKCD), transcript variant 1, mRNA. | 2031 | GC-A0211 |
| ERBB4 | NM_005235.3 | Human | Homo sapiens erb-b2 receptor tyrosine kinase 4 (ERBB4), transcript variant JM-a/CVT-1, mRNA. | 3927 | GC-A0212 |
| ITK | NM_005546.4 | Human | Homo sapiens IL2 inducible T cell kinase (ITK), mRNA. | 1863 | GC-A0222 |
| GRK5 | NM_005308.3 | Human | Homo sapiens G protein-coupled receptor kinase 5 (GRK5), mRNA. | 1773 | GC-A0230 |
| CAMK4 | NM_001744.4 | Human | Homo sapiens calcium/calmodulin-dependent protein kinase IV (CAMK4), mRNA. | 1422 | GC-A0231 |
| DDR1 | NM_013993.3 | Human | Homo sapiens discoidin domain receptor tyrosine kinase 1 (DDR1), transcript variant 2, mRNA. | 2742 | GC-A0234 |
| PSKH1 | NM_006742.3 | Human | Homo sapiens protein serine kinase H1 (PSKH1), mRNA. | 1275 | GC-A0235 |
| PRKACB | NM_002731.4 | Human | Homo sapiens protein kinase cAMP-activated catalytic subunit beta (PRKACB), transcript variant 2, mRNA. | 1056 | GC-A0258 |
| FGFR1 | NM_023106.3 | Human | Homo sapiens fibroblast growth factor receptor 1 (FGFR1), transcript variant 4, mRNA. | 2196 | GC-A0260 |
| EIF2AK2 | NM_002759.4 | Human | Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), transcript variant 1, mRNA. | 1656 | GC-A0265 |
| GRK2 | NM_001619.5 | Human | Homo sapiens G protein-coupled receptor kinase 2 (GRK2), mRNA. | 2070 | GC-A0311 |
| PRKACA | NM_002730.4 | Human | Homo sapiens protein kinase cAMP-activated catalytic subunit alpha (PRKACA), transcript variant 1, mRNA. | 1056 | GC-A0326 |
| CDK16 | NM_006201.5 | Human | Homo sapiens cyclin dependent kinase 16 (CDK16), transcript variant 1, mRNA. | 1491 | GC-A0347 |
| CDK5 | NM_004935.4 | Human | Homo sapiens cyclin dependent kinase 5 (CDK5), transcript variant 1, mRNA. | 879 | GC-A0348 |
| TGFA | NM_001099691.3 | Human | Homo sapiens transforming growth factor alpha (TGFA), transcript variant 2, mRNA. | 480 | GC-A0352 |
| MAPK1 | NM_002745.5 | Human | Homo sapiens mitogen-activated protein kinase 1 (MAPK1), transcript variant 1, mRNA. | 1083 | GC-A0354 |
| FER | NM_005246.4 | Human | Homo sapiens FER tyrosine kinase (FER), transcript variant 1, mRNA. | 2469 | GC-A0374 |
| PRKCH | NM_006255.5 | Human | Homo sapiens protein kinase C eta (PRKCH), mRNA. | 2052 | GC-A0394 |
| PRKG1 | NM_006258.4 | Human | Homo sapiens protein kinase cGMP-dependent 1 (PRKG1), transcript variant 2, mRNA. | 2061 | GC-A0409 |
| GRK6 | NM_001004106.3 | Human | Homo sapiens G protein-coupled receptor kinase 6 (GRK6), transcript variant 1, mRNA. | 1731 | GC-A0473 |
| FYN | NM_002037.5 | Human | Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 1, mRNA. | 1614 | GC-A0485 |
| ROR1 | NM_005012.4 | Human | Homo sapiens receptor tyrosine kinase like orphan receptor 1 (ROR1), transcript variant 1, mRNA. | 2814 | GC-A0499 |
| FRK | NM_002031.3 | Human | Homo sapiens fyn related Src family tyrosine kinase (FRK), mRNA. | 1518 | GC-A0509 |
| KIT | NM_000222.3 | Human | Homo sapiens KIT proto-oncogene, receptor tyrosine kinase (KIT), transcript variant 1, mRNA. | 2931 | GC-A0519 |
| PRKAR2A | NM_004157.4 | Human | Homo sapiens protein kinase cAMP-dependent type II regulatory subunit alpha (PRKAR2A), transcript variant 1, mRNA. | 1215 | GC-A0524 |
| BTK | NM_000061.3 | Human | Homo sapiens Bruton tyrosine kinase (BTK), transcript variant 1, mRNA. | 1980 | GC-A0534 |
| CAMK1 | NM_003656.5 | Human | Homo sapiens calcium/calmodulin dependent protein kinase I (CAMK1), mRNA. | 1113 | GC-A0562 |
| NEK2 | NM_002497.4 | Human | Homo sapiens NIMA related kinase 2 (NEK2), transcript variant 1, mRNA. | 1338 | GC-A0662 |
| MAP2K4 | NM_003010.4 | Human | Homo sapiens mitogen-activated protein kinase kinase 4 (MAP2K4), transcript variant 1, mRNA. | 1200 | GC-A0727 |
| BLK | NM_001715.3 | Human | Homo sapiens BLK proto-oncogene, Src family tyrosine kinase (BLK), transcript variant 1, mRNA. | 1518 | GC-A0751 |
| STK38 | NM_001305102.2 | Human | Homo sapiens serine/threonine kinase 38 (STK38), transcript variant 2, mRNA. | 1398 | GC-A0772 |
| MAP2K1 | NM_002755.4 | Human | Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. | 1182 | GC-A0826 |
| CAMK2G | NM_172170.5 | Human | Homo sapiens calcium/calmodulin dependent protein kinase II gamma (CAMK2G), transcript variant 3, mRNA. | 1557 | GC-A0838 |
