简介
神经系统包括中枢神经系统（CNS）和周围神经系统（PNS）。病毒感染、中毒、遗传缺陷、免疫损伤、代谢紊乱等，均可能引发神经系统疾病的发生。神经系统自身免疫性疾病是人体免疫系统错误地攻击自身神经系统而造成神经系统组织结构和功能损伤的一类疾病。该类疾病损伤范围广泛，临床表现复杂多样，可以累及中枢神经系统、周围神经系统以及神经-肌肉接头处，导致神经元或轴索损伤、髓鞘脱失、神经-肌肉接头破坏等病理改变。
如中枢神经系统自身免疫性疾病，包括视神经脊髓炎谱系疾病（NMOSD）、髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）、多发性硬化（MS）、急性播散性脑脊髓炎（ADEM）、自身免疫性脑炎（AE）、CNS血管炎等。这些疾病具有相对独立的临床特征，一些特异性抗体在疾病的诊断与鉴别诊断中起着不可或缺的作用。例如，NMOSD患者可能出现AQP4抗体阳性、ADEM患者可能出现MOG抗体阳性等。本克隆套装可用于神经免疫疾病生物标志物研发，扩展和完善神经免疫疾病体液标志物谱，进一步用于疾病鉴别诊断、病程监控、疗效预后评估、药物靶点筛选等。
图1：中枢神经系统（CNS）髓鞘蛋白的分布
套装信息
| 货号 | 物种 | 基因数 | 载体 | 载体类型 | 价格 |
|---|---|---|---|---|---|
| OC-GF021-M02 | Human | 2137 | pReceiver-M02 | Expression-ready Non-viral | Inquire |
| OC-GF021-M35 | Human | 2137 | pReceiver-M35 | Expression-ready Non-viral | Inquire |
| OC-GF021-M98 | Human | 2137 | pReceiver-M98 | Expression-ready Non-viral | Inquire |
| OC-GF021-Lv105 | Human | 2137 | pReceiver-Lv105 | Expression-ready Lentiviral | Inquire |
| OC-GF021-Lv242 | Human | 2137 | pReceiver-Lv242 | Expression-ready Lentiviral | Inquire |
| OC-GF021-GC | Human | 2137 | pDONR™ Vector | Gateway shuttle | Inquire |
克隆列表
如需克隆列表请通过电话（4006-020-200）或邮件（sales@igenebio.com）联系我们。
| Symbol | NCBI注册号 | 物种 | 基因描述 | ORF length(bp) | 产品ID |
| HTR3B | NM_006028.5 | Human | Homo sapiens 5-hydroxytryptamine receptor 3B (HTR3B), transcript variant 1, mRNA. | 1326 | GC-U0382 |
| KCNH1 | NM_172362.3 | Human | Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA. | 2970 | GC-Z2907 |
| PCDH8 | NM_002590.4 | Human | Homo sapiens protocadherin 8 (PCDH8), transcript variant 1, mRNA. | 3213 | GC-A6372 |
| MT3 | NM_005954.4 | Human | Homo sapiens metallothionein 3 (MT3), mRNA. | 207 | GC-T3737 |
| NR4A1 | NM_001202233.2 | Human | Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 3, mRNA. | 1836 | GC-A1310 |
| NR4A1 | NM_001202234.2 | Human | Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 4, mRNA. | 1959 | GC-A4501 |
| NR4A1 | NM_173157.3 | Human | Homo sapiens nuclear receptor subfamily 4 group A member 1 (NR4A1), transcript variant 2, mRNA. | 1797 | GC-A1311 |
| CAPRIN1 | NM_005898.5 | Human | Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript variant 1, mRNA. | 2130 | GC-Y3977 |
| CAPRIN1 | NM_203364.3 | Human | Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript variant 2, mRNA. | 2085 | GC-Z5446 |
| GPR176 | NM_001271854.2 | Human | Homo sapiens G protein-coupled receptor 176 (GPR176), transcript variant 2, mRNA. | 1545 | GC-A3513 |
| GPR176 | NM_007223.3 | Human | Homo sapiens G protein-coupled receptor 176 (GPR176), transcript variant 1, mRNA. | 1548 | GC-A0542 |
| GRM2 | NM_000839.5 | Human | Homo sapiens glutamate metabotropic receptor 2 (GRM2), transcript variant 1, mRNA. | 2619 | GC-A0723 |
| YBX1 | NM_004559.5 | Human | Homo sapiens Y-box binding protein 1 (YBX1), transcript variant 1, mRNA. | 975 | GC-Z2227 |
| SPG11 | NM_025137.4 | Human | Homo sapiens SPG11 vesicle trafficking associated, spatacsin (SPG11), transcript variant 1, mRNA. | 7332 | GC-E3411 |
| FZD4 | NM_012193.4 | Human | Homo sapiens frizzled class receptor 4 (FZD4), mRNA. | 1614 | GC-U0507 |
| CORO1C | NM_001276471.2 | Human | Homo sapiens coronin 1C (CORO1C), transcript variant 3, mRNA. | 1425 | GC-V0380 |
| PDE7B | NM_018945.4 | Human | Homo sapiens phosphodiesterase 7B (PDE7B), mRNA. | 1353 | GC-U0877 |
| SLC40A1 | NM_014585.6 | Human | Homo sapiens solute carrier family 40 member 1 (SLC40A1), mRNA. | 1716 | GC-U0652 |
| RAB26 | NM_001308053.1 | Human | Homo sapiens RAB26, member RAS oncogene family (RAB26), transcript variant 2, mRNA. | 573 | GC-U0581 |
| RPS13 | NM_001017.3 | Human | Homo sapiens ribosomal protein S13 (RPS13), mRNA. | 456 | GC-F0132 |
| RPS18 | NM_022551.3 | Human | Homo sapiens ribosomal protein S18 (RPS18), mRNA. | 459 | GC-F0609 |
| RPS14 | NM_001025071.2 | Human | Homo sapiens ribosomal protein S14 (RPS14), transcript variant 1, mRNA. | 456 | GC-F0356 |
| RPS16 | NM_001020.6 | Human | Homo sapiens ribosomal protein S16 (RPS16), transcript variant 1, mRNA. | 441 | GC-F0306 |
| RPS15A | NM_001030009.2 | Human | Homo sapiens ribosomal protein S15a (RPS15A), transcript variant 1, mRNA. | 393 | GC-F0583 |
| RTN3 | NM_006054.4 | Human | Homo sapiens reticulon 3 (RTN3), transcript variant 1, mRNA. | 711 | GC-V0138 |
| RTN3 | NM_201428.3 | Human | Homo sapiens reticulon 3 (RTN3), transcript variant 2, mRNA. | 3042 | GC-Z3044 |
| UNC5C | NM_003728.3 | Human | Homo sapiens unc-5 netrin receptor C (UNC5C), mRNA. | 2796 | GC-A3946 |
| DNAJB1 | NM_001300914.2 | Human | Homo sapiens DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), transcript variant 2, mRNA. | 723 | GC-I2174 |
| DNAJB1 | NM_006145.3 | Human | Homo sapiens DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1), transcript variant 1, mRNA. | 1023 | GC-T0399 |
| GABARAP | NM_007278.2 | Human | Homo sapiens GABA type A receptor-associated protein (GABARAP), mRNA. | 354 | GC-I0146 |
| ARF1 | NM_001658.4 | Human | Homo sapiens ADP ribosylation factor 1 (ARF1), transcript variant 4, mRNA. | 546 | GC-A0306 |
| NETO2 | NM_018092.5 | Human | Homo sapiens neuropilin and tolloid like 2 (NETO2), transcript variant 1, mRNA. | 1578 | GC-H0314 |
| ATAD1 | NM_032810.4 | Human | Homo sapiens ATPase family AAA domain containing 1 (ATAD1), transcript variant 1, mRNA; nuclear gene for mitochondrial product. | 1086 | GC-E1659 |
| CALM3 | NM_001329925.2 | Human | Homo sapiens calmodulin 3 (CALM3), transcript variant 6, mRNA. | 342 | GC-A8631 |
| CALM3 | NM_005184.4 | Human | Homo sapiens calmodulin 3 (CALM3), transcript variant 1, mRNA. | 450 | GC-A0377 |
| GJD2 | NM_020660.3 | Human | Homo sapiens gap junction protein delta 2 (GJD2), mRNA. | 966 | GC-T1262 |
| STX10 | NM_001271611.2 | Human | Homo sapiens syntaxin 10 (STX10), transcript variant 4, mRNA. | 603 | GC-Z0174 |
| STX10 | NM_003765.3 | Human | Homo sapiens syntaxin 10 (STX10), transcript variant 1, mRNA. | 750 | GC-U0157 |
| SPARCL1 | NM_001128310.3 | Human | Homo sapiens SPARC like 1 (SPARCL1), transcript variant 1, mRNA. | 1995 | GC-Z6357 |
| SPARCL1 | NM_001291977.2 | Human | Homo sapiens SPARC like 1 (SPARCL1), transcript variant 4, mRNA. | 1620 | GC-A5795 |
| SPARCL1 | NM_004684.6 | Human | Homo sapiens SPARC like 1 (SPARCL1), transcript variant 2, mRNA. | 1995 | GC-D0257 |
| FBXL20 | NM_032875.3 | Human | Homo sapiens F-box and leucine rich repeat protein 20 (FBXL20), transcript variant 1, mRNA. | 1311 | GC-Z1248 |
| BLOC1S6 | NM_012388.4 | Human | Homo sapiens biogenesis of lysosomal organelles complex 1 subunit 6 (BLOC1S6), transcript variant 2, mRNA. | 519 | GC-U0952 |
| MKLN1 | NM_001321316.2 | Human | Homo sapiens muskelin 1 (MKLN1), transcript variant 3, mRNA. | 1587 | GC-T2699 |
| MKLN1 | NM_013255.5 | Human | Homo sapiens muskelin 1 (MKLN1), transcript variant 2, mRNA. | 2208 | GC-T9061 |
| TTYH1 | NM_020659.4 | Human | Homo sapiens tweety family member 1 (TTYH1), transcript variant 1, mRNA. | 1353 | GC-U1041 |
| NQO1 | NM_000903.3 | Human | Homo sapiens NAD(P)H quinone dehydrogenase 1 (NQO1), transcript variant 1, mRNA. | 825 | GC-Z0563 |
| NQO1 | NM_001025433.2 | Human | Homo sapiens NAD(P)H quinone dehydrogenase 1 (NQO1), transcript variant 2, mRNA. | 723 | GC-Z3579 |
| KCNN2 | NM_170775.3 | Human | Homo sapiens potassium calcium-activated channel subfamily N member 2 (KCNN2), transcript variant 2, mRNA. | 696 | GC-L8848 |
| SLC12A5 | NM_001134771.1 | Human | Homo sapiens solute carrier family 12 member 5 (SLC12A5), transcript variant 1, mRNA. | 3420 | GC-Y4646 |
