复能易锦提供的全部人类和小鼠ORF克隆及相关慢病毒和AAV病毒，所提供的载体质粒均采用毛细管电泳sanger全长测序验证，并承诺编码的氨基酸序列与NCBI数据库匹配。
All human and mice ORF clones and related Lentivirus, AAV particles and recombinant proteins provided by iGeneBio are fully sequenced using Sanger sequencing by capillary electrophoresis and Amino Acid Sequences are guaranteed to be matched with NCBI database.

预制稳转株（Stable cell lines）

点击访问GeneHero™ Cas9 稳定表达细胞系、GeneHero™ CRISPRa预制稳转株、GeneHero™ CRISPRi 预制稳转株、预制肿瘤细胞稳转株产品页面

2025

Cheng, L., et al. (2025). PEBP1 amplifies mitochondrial dysfunction-induced integrated stress response. eLife DOI: 10.7554/eLife.102852 [GeneHero™ HEK293T Cas9-expressing stable cell line, Cat. No. SL502]
Yuan, Y., et al. (2025). A multistage drug delivery approach for colorectal primary tumors and lymph node metastases. Nat Commun DOI: 10.1038/s41467-025-56768-z [Luciferase/GFP Dual‐labeled COLO 205 Cancer Cell Line, Cat. No. SL005]

2024

Gupta, S., et al. (2024). Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers. J Gen Physiol DOI: 10.1085/jgp.202413676 [GeneHero™ HEK293T Cas9-expressing stable cell line, Cat. No. SL502]
Liu, X., et al. (2024). Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis. J Clin Invest DOI: 10.1172/JCI179527 [Luciferase/GFP Dual‐labeled 4T-1 and CT26 Cancer Cell Lines, Cat. No. SL020, SL021]
Stearns, K., et al. (2024). Human parainfluenza virus 3 field strains undergo extracellular fusion protein cleavage to activate entry. mBio DOI: 10.1128/mbio.02327-24 [GeneHero™ CRISPRa Stable Cell Lines HEK293 stably expressing dCas9-VP64 and MPH complex, Cat. No. SL302]
Hajj, S.E., et al. (2024). Bone Spheroid Development Under Flow Conditions with Mesenchymal Stem Cells and Human Umbilical Vein Endothelial Cells in a 3D Porous Hydrogel Supplemented with Hydroxyapatite. Gels DOI: 10.3390/gels10100666 [Human bone marrow-derived mesenchymal stem cell stably expressing SV40 large T antigen and hTERT gene, Cat. No. SL428]
Moreno, P., et al. (2024). ADRA2A promotes the classical/progenitor subtype and reduces disease aggressiveness of pancreatic cancer. bioRxiv. DOI: 10.1101/2024.03.12.584316 [OMICSLINK™ Human ADRA2A ORF expression clone and empty control, Cat. No. EX-Z5688-Lv103, EX-NEG-Lv103; Lenti-Pac™ HIV Expression Packaging Kit Cat. No. LT001]
Kocabiyik, O., et al. (2024). Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract. Sci Adv. DOI: 10.1126/sciadv.adn7786 [Firefly Luciferase + eGFP Lentifect™ SARS-CoV-2 D614G Spike-Pseudotyped Lentiviral Particles, ER retention signal removed, Cat. No. SP003-100; HEK293T cells stably expressing human ACE2 (NM_021804.2), Cat. No. SL221]
Guo, B., et al. (2024). Enhanced ApcMin/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells. Neoplasia. DOI: 10.1016/j.neo.2024.101005 [Luciferase/GFP Dual‐labeled CT26 Cancer Cell Line, Cat. No. SL021]
Chen, K.M., et al. (2024). Targeting PD-L1 in solid cancer with myeloid cells expressing a CAR-like immune receptor. Front Immunol. DOI: 10.3389/fimmu.2024.1380065 [Luciferase/GFP Dual‐labeled MDA-MB-231 Cancer Cell Line, Cat. No. SL018]
Bacigalupa, Z.A., et al. (2024). HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma. J Clin Invest. DOI: 10.1172/JCI164249 [GeneHero™ 786-O Cas9-expressing stable cell line, Cat. No. SL577]
Elste, J., et al. (2024). Co-Expression of Niemann-Pick Type C1-Like1 (NPC1L1) with ACE2 Receptor Synergistically Enhances SARS-CoV-2 Entry and Fusion. Biomedicines. DOI: 10.3390/biomedicines12040821 [ACE2-expressing HEK293T stable cell line]
Silva, W.N., et al. (2024). Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression. Int J Nanomedicine. DOI: 10.2147/IJN.S452896 [Luciferase/GFP Dual‐labeled COLO 205 Cancer Cell Line, Cat. No.SL005]
Lutfiye Yildiz Ozer, et al. 2024.Development of a cancer metastasis-on-chip assay for high throughput drug screening. Front Oncol. DOI: 10.3389/fonc.2023.1269376 [stably expressed GFP of a pre-made eGFP-puro-CMV-lentiviral vector]
Asim G. Khan, et al. 2024.An experimental census of retrons for DNA production and genome editing. bioRxiv. DOI: 10.1101/2024.01.25.577267 [HEK293T Cell Line Stably Expressing CRISPR Cas9 Nuclease]

2023

Madeline Dahut, et al. 2023. Fulvestrant increases the susceptibility of enzalutamide-resistant prostate cancer cells to NK-mediated lysis. J Immunother Cancer. DOI: 10.1136/jitc-2023-007386 [Short tandem repeat (STR) profiling]
Rachel Erickson, et al. 2023.SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition. Nat Commun. DOI: 10.1038/s41467-023-42140-6 [ACE2-expressing 293T cells, Cat.No. SL221; Luc-Pair™ Firefly Luciferase HS Assay Kit, Cat. No.LF007]
Min Luo, et al. 2023.A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal. Signal Transduct Target Ther. DOI: 10.1038/s41392-023-01545-x [Luciferase/GFP Dual‐labeled CT-26 Cancer Cell Line]
Elste, J., et al. (2023). Plant Cell-Engineered Gold Nanoparticles Conjugated to Quercetin Inhibit SARS-CoV-2 and HSV-1 Entry. Int J Mol Sci. doi: 10.3390/ijms241914792 [Lentifect™ SARS-CoV-2 D614G Spike-Pseudotyped Lentiviral Particles; Lenti-Pac™ HEK293T cell line]
Grimes, S.M., et al. (2023). Single-cell multi-gene identification of somatic mutations and gene rearrangements in cancer. NAR Cancer doi: 10.1093/narcan/zcad034 [GeneHero™ Jurkat Cas9-expressing stable cell line]
Shin, S.M., et al. (2023). Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels. Mol Pain doi: 10.1177/17448069231174315 [GeneHero™ Neuro2a Cas9-expressing stable cell line]
Kuroda, T., et al. (2023). Efficacy comparison of 3CL protease inhibitors ensitrelvir and nirmatrelvir against SARS-CoV-2 in vitro and in vivo. J Antimicrob Chemother doi: 10.1093/jac/dkad027 [ACE2 and TMPRSS2-expressing HEK293T cells]
Morimoto, M., et al. (2023). Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment. NPJ Genom Med doi: 10.1038/s41525-022-00343-8 [GeneHero™ HeLa Cas9-expressing stable cell line]
Osaka, T., et al. (2023). Cross-Reactivity of Antibodies in Intravenous Immunoglobulin Preparation for Protection against SARS-CoV-2. Microorganisms doi: 10.3390/microorganisms11020471 [ACE2- and TMPRSS2-expressing HEK293T stable cell line]
Chan, J.F-K., et al. (2023). Altered host protease determinants for SARS-CoV-2 Omicron. Sci Adv doi: 10.1126/sciadv.add3867 [ACE2-expressing HEK293T stable cell line]
Koch, J., et al. (2023). Establishing a New Platform to Investigate the Efficacy of Oncolytic Virotherapy in a Human Ex Vivo Peritoneal Carcinomatosis Model. Viruses doi: 10.3390/v15020363 [GFP dual-labeled HT-29 cancer cell line]
Merluza, J., et al. (2023). Validation and Establishment of the SARS-CoV-2 Lentivirus Surrogate Neutralization Assay as a Prescreening Tool for the Plaque Reduction Neutralization Test. Microbiol Spectr doi: 10.1128/spectrum.03789-22 [ACE2- and TMPRSS2-expressing HEK293T stable cell line]
Nakata, Y., et al. (2023). Cellular APOBEC3A deaminase drives mutations in the SARS-CoV-2 genome. Nucleic Acids Res doi: 10.1093/nar/gkac1238 [ACE2- and TMPRSS2-expressing HEK293T stable cell line]

2022

Chen, Y.A., et al. (2022). In vivo genome editing using novel AAV-PHP variants rescues motor function deficits and extends survival in a SOD1-ALS mouse model. Gene Ther doi: 10.1038/s41434-022-00375-w [GeneHero™ HeLa Cas9-expressing stable cell line]
Travis, B.J., et al. (2022). Significance of chlorine‐dioxide‐based oral rinses in preventing SARS‐CoV‐2 cell entry. Oral Dis doi: 10.1111/odi.14319 [ACE2-expressing HEK293T stable cell line; Lentifect™ SARS-CoV-2 D614G Spike-Pseudotyped Lentiviral Particles]
Wang, X., et al. (2022). Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis. Neuron doi: 10.1016/j.neuron.2022.10.028 [Neuro2a stably expressing Cas9 from ROSA26 site]
Zhang, W.F., et al. (2022). SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity. J Clin Invest doi: 10.1172/JCI151803 [Neuro2a stably expressing Cas9 from ROSA26 site]
Moreau, F., et al. (2022). Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nat Commun doi: 10.1038/s41467-022-34391-6 [GFP dual-labeled MCF7 cancer cell line]
Kim, Y.S., et al. (2022). Mulberry Component Kuwanon C Exerts Potent Therapeutic Efficacy In Vitro against COVID-19 by Blocking the SARS-CoV-2 Spike S1 RBD:ACE2 Receptor Interaction. Int J Mol Sci doi: 10.3390/ijms232012516 [ACE2- and TMPRSS2-expressing HEK293T stable cell line]
Kim, Y.S., et al. (2022). Mulberrofuran G; a Mulberry Component; Prevents SARS-CoV-2 Infection by Blocking the Interaction between SARS-CoV-2 Spike Protein S1 Receptor-Binding Domain and Human Angiotensin-Converting Enzyme 2 Receptor. Nutrients doi: 10.3390/nu14194170 [ACE2- and TMPRSS2-expressing HEK293T stable cell line]
Luo, W.S., et al. (2022). Pcdh11x controls target specification of mossy fiber sprouting. Front Neurosci doi: 10.3389/fnins.2022.888362 [Mouse cell line Neuro2a stably expressing Cas9 from ROSA26 site]
Han, S.T., et al. (2022). PUS7 deficiency in human patients causes profound neurodevelopmental phenotype by dysregulating protein translation. Molecular Genetics and Metabolism doi: 10.1016/j.ymgme.2022.01.103 [GeneHero™ HeLa Cas9-expressing stable cell line]
Hwang, J-Y., et al. (2022). Humoral and Cellular Responses to COVID-19 Vaccines in SARS-CoV-2 Infection-Naïve and -Recovered Korean Individuals. Vaccines doi: 10.3390/vaccines10020332 [ACE2-expressing HEK293T stable cell line]
Fereydouni, M., et al. (2022). Human Tumor Targeted Cytotoxic Mast Cells for Cancer Immunotherapy. Frontiers in Oncology doi: 10.3389/fonc.2022.871390 [Luciferase + GFP labeled SK-BR-3 cell line]
Park, H., et al. (2022). TMED3 Complex Mediates ER Stress-Associated Secretionof CFTR, Pendrin, and SARS-CoV-2 Spike. Advanced Science doi: 10.1002/advs.202105320 [ACE2- and TMPRSS2-expressing HEK293T stable cell line]
Sim, J-R., et al. (2022). Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition. Cell Reports doi: 10.1016/j.celrep.2022.111117 [ACE2- and TMPRSS2-expressing HEK293T stable cell line]
Grodzki, M., et al. (2022). Genome-scale CRISPR screens identify host factors that promote human coronavirus infection. Genome Medicine doi: 10.1186/s13073-022-01013-1 [ACE2-expressing HEK293T stable cell line]
Ariumi, Y. (2022). Host Cellular RNA Helicases Regulate SARS-CoV-2 Infection. Journal of Virology doi: 10.1128/jvi.00002 [ACE2-expressing HEK293T stable cell line]
Pivniouk, V., et al. (2022). The OM-85 bacterial lysate inhibits SARS-CoV-2 infection of epithelial cells by downregulating SARS-CoV-2 receptor expression. Journal of Allergy and Clinical Immunology doi: 10.1016/j.jaci.2021.11.019 [ACE2-expressing HEK293T stable cell line]
Travis, B.J., et al. (2022). Significance of chlorine-dioxide-based oral rinses in preventing SARS-CoV-2 cell entry. Oral Diseases doi: 10.1111/odi.14319 [ACE2-expressing HEK293T stable cell line]
Zheng, W., et al. (2022). SIRT1 inactivation switches reactive astrocytes to an anti-inflammatory phenotype in CNS autoimmunity. The Journal of Clinical Investigation doi: 10.1172/JCI151803 [GeneHero™ Neuro2a Cas9-expressing stable cell line]

2021

Hashizume, M., et al. (2021). Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro. Viruses doi: 10.3390/v13010067 [ACE2-expressing HEK293T stable cell line]
Hana, S., et al. (2021) Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice. Gene Thereapy doi: 10.1038/s41434-021-00224-2 [GeneHero™ HeLa, Neuro2a Cas9-expressing stable cell lines]
Beitzel, B.F., et al. (2021). On‐Demand Patient‐Specific Phenotype‐to‐Genotype Ebola Virus Characterization. Viruses doi: 10.3390/ v13102010 [Custom stable cell line services]
Paidi, R.K., et al. (2021). Eugenol, a Component of Holy Basil (Tulsi) and Common Spice Clove, Inhibits the Interaction Between SARS-CoV-2 Spike S1 and ACE2 to Induce Therapeutic Responses. Journal of Neuroimmune Pharmacology doi: 10.1007/s11481-021-10028-1 [ACE2-expressing HEK293T stable cell line]
Song, Y., et al. (2021). A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis. PLOS Pathogens doi: 10.1371/journal.ppat.1010141 [GeneHero™ A549 Cas9-expressing stable cell line]
Paidi, R.K., et al. (2021). Selective Inhibition of the Interaction between SARS-CoV-2 Spike S1 and ACE2 by SPIDAR Peptide Induces Anti-Inflammatory Therapeutic Responses. Journal of Immunology doi: 10.4049/jimmunol.2100144 [ACE2-expressing HEK293T stable cell line]

2020

Kasper, S.H., et al. (2020). Colorectal cancer-associated anaerobic bacteria proliferate in tumor spheroids and alter the microenvironment. Scientific Reports doi: 10.1038/s41598-020-62139-z [GFP labeled HT-29 cell line]
Reznikov, L.R., et al. (2020). Identification of antiviral antihistamines for COVID-19 repurposing. Biochemical and Biophysical Research Communications doi: 10.1016/j.bbrc.2020.11.095 [ACE2-expressing HEK293T stable cell line]
Pan, Y., et al. (2020). The nature of the modification at position 37 oftRNAPhecorrelates with acquired taxol resistance. Nucleic Acids Research doi: 10.1093/nar/gkaa1164 [TYW2 stable knockdown HeLa cell line]
Chaudhari, H.G., et al. (2020). Evaluation of Homology-Independent CRISPR-Cas9Off-Target Assessment Methods. The CRISPR Journal doi: 10.1089/crispr.2020.0053 [GeneHero™ HEK293 Cas9-expressing stable cell line]

2019

Howell, M.C., et al. (2019). Lung cancer cells survive epidermal growth factor receptor tyrosine kinase inhibitor exposure through upregulation of cholesterol synthesis. FASEB Bio Advances doi: 10.1096/fba.2019-00081 [GFP labeled H1975 cell line]

2018

Sokhi, U.K., et al. (2018). Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models. Nature Communications. DOI: 10.1038/s41467-018-03081-7. [HEK293 Cas9-expressing stable cell line]
Zhao, D., et al. (2018). Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Molecular Cell. DOI: 10.1016/j.molcel.2018.01.017. [HeLa, HEK293 and A549 Cas9-expressing stable cell lines]

2017

Shen, J.P., et al. (2017). Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions. Nature Methods doi 10.1038/nmeth.4225. [HeLa, HEK293 and A549 Cas9-expressing stable cell lines]
Mitchell, M.J., et al. (2017). Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nature Communications. DOI: 10.1038/ncomms14179. [dual-labelled luciferase and GFP+ COLO 205 colon cancer cell line]

预制稳转株（Stable cell lines）

在线客服

技术电话

微信扫码