简介
蛋白酶抑制剂是抑制蛋白酶功能的分子，许多天然存在的蛋白酶抑制剂是蛋白质。蛋白酶抑制剂可用作抗病毒药物，FDA已批准上市7种蛋白酶抑制剂药物包括SQV、RTV、IDV、NFV、APV等。根据氨基酸序列的同源性和靶向蛋白酶的不同，蛋白酶抑制剂又可分为丝氨酸蛋白酶抑制剂、半胱氨酸蛋白酶抑制剂、天冬氨酸蛋白酶抑制剂以及金属蛋白酶抑制剂。蛋白酶及其抑制剂关键氨基酸的突变，可以影响其生理功能、稳定性、催化活性、抑制特异性等。挖掘自然界蛋白酶及其抑制剂的各种突变体，分析它们的关键活性位点，并运用蛋白质工程手段改造和设计活性更强、稳定性更高、特异性更好、环境更友好、成本更低的蛋白酶及其抑制剂，已成为当前的热点研究之一。
套装信息
| 新货号 | 旧货号 | 物种 | 基因数 | 载体 | 载体类型 | 价格 |
|---|---|---|---|---|---|---|
| OC-GF017-M02 | OC-HPI-M02 | Human | 154 | pReceiver-M02 | Expression-ready Non-viral | Inquire |
| OC-GF017-M35 | OC-HPI-M35 | Human | 154 | pReceiver-M35 | Expression-ready Non-viral | Inquire |
| OC-GF017-M98 | OC-HPI-M98 | Human | 154 | pReceiver-M98 | Expression-ready Non-viral | Inquire |
| OC-GF017-Lv105 | OC-HPI-Lv105 | Human | 154 | pReceiver-Lv105 | Expression-ready Lentiviral | Inquire |
| OC-GF017-Lv242 | OC-HPI-Lv242 | Human | 154 | pReceiver-Lv242 | Expression-ready Lentiviral | Inquire |
| OC-GF017-GC | OC-HPI-GC | Human | 154 | pDONR™ Vector | Gateway shuttle | Inquire |
克隆列表
表格仅包含克隆套装部分内容，如需更多信息请通过电话（4006-020-200）或邮件（sales@igenebio.com）联系我们。
| Symbol | NCBI注册号 | 物种 | 基因描述 | ORF length(bp) | 产品ID |
| CD109 | NM_133493.5 | Human | Homo sapiens CD109 molecule (CD109), transcript variant 1, mRNA. | 4338 | GC-E1159 |
| COL7A1 | NM_000094.4 | Human | Homo sapiens collagen type VII alpha 1 chain (COL7A1), mRNA. | 8835 | GC-M0164 |
| SPINT1 | NM_003710.4 | Human | Homo sapiens serine peptidase inhibitor, Kunitz type 1 (SPINT1), transcript variant 2, mRNA. | 1542 | GC-M0314 |
| XIAP | NM_001204401.2 | Human | Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript variant 2, mRNA. | 1494 | GC-T0104 |
| KAZALD1 | NM_030929.5 | Human | Homo sapiens Kazal type serine peptidase inhibitor domain 1 (KAZALD1), transcript variant 1, mRNA. | 915 | GC-V1110 |
| WFDC5 | NM_145652.4 | Human | Homo sapiens WAP four-disulfide core domain 5 (WFDC5), transcript variant 1, mRNA. | 372 | GC-Y2198 |
| SERPINE1 | NM_000602.5 | Human | Homo sapiens serpin family E member 1 (SERPINE1), transcript variant 2, mRNA. | 1209 | GC-F0606 |
| WFDC2 | NM_006103.4 | Human | Homo sapiens WAP four-disulfide core domain 2 (WFDC2), mRNA. | 375 | GC-Z1019 |
| SPINT1 | NM_181642.3 | Human | Homo sapiens serine peptidase inhibitor, Kunitz type 1 (SPINT1), transcript variant 1, mRNA. | 1590 | GC-Z5300 |
| C3 | NM_000064.4 | Human | Homo sapiens complement C3 (C3), mRNA. | 4992 | GC-E2587 |
| CD109 | NM_001159587.3 | Human | Homo sapiens CD109 molecule (CD109), transcript variant 2, mRNA. | 4287 | GC-E2721 |
| CD109 | NM_001159588.3 | Human | Homo sapiens CD109 molecule (CD109), transcript variant 3, mRNA. | 4107 | GC-E2722 |
| XIAP | NM_001167.4 | Human | Homo sapiens X-linked inhibitor of apoptosis (XIAP), transcript variant 1, mRNA. | 1494 | GC-H4489 |
| SERPINB2 | NM_001143818.2 | Human | Homo sapiens serpin family B member 2 (SERPINB2), transcript variant 1, mRNA. | 1248 | GC-Z6805 |
| AMBP | NM_001633.4 | Human | Homo sapiens alpha-1-microglobulin/bikunin precursor (AMBP), mRNA. | 1059 | GC-G0166 |
| APLP2 | NM_001642.3 | Human | Homo sapiens amyloid beta precursor like protein 2 (APLP2), transcript variant 1, mRNA. | 2292 | GC-Y2612 |
| APLP2 | NM_001142278.2 | Human | Homo sapiens amyloid beta precursor like protein 2 (APLP2), transcript variant 4, mRNA. | 1569 | GC-Y4654 |
| APP | NM_201414.3 | Human | Homo sapiens amyloid beta precursor protein (APP), transcript variant 3, mRNA. | 2088 | GC-F0776 |
| APP | NM_000484.4 | Human | Homo sapiens amyloid beta precursor protein (APP), transcript variant 1, mRNA. | 2313 | GC-Z2553 |
| APP | NM_201413.3 | Human | Homo sapiens amyloid beta precursor protein (APP), transcript variant 2, mRNA. | 2256 | GC-Z3473 |
| APP | NM_001136130.3 | Human | Homo sapiens amyloid beta precursor protein (APP), transcript variant 6, mRNA. | 2145 | GC-Z6628 |
| BCL2L1 | NM_001317921.2 | Human | Homo sapiens BCL2 like 1 (BCL2L1), transcript variant 5, mRNA. | 702 | GC-B0212 |
| BCL2L1 | NM_001191.4 | Human | Homo sapiens BCL2 like 1 (BCL2L1), transcript variant 2, mRNA. | 513 | GC-Z2522 |
| BIRC5 | NM_001012270.2 | Human | Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2, mRNA. | 414 | GC-Z3551 |
| C4B | NM_001002029.4 | Human | Homo sapiens complement C4B (Chido blood group) (C4B), mRNA. | 5235 | GC-E2592 |
| CAST | NM_001042444.3 | Human | Homo sapiens calpastatin (CAST), transcript variant 10, mRNA. | 2004 | GC-T9667 |
| CRIM1 | NM_016441.3 | Human | Homo sapiens cysteine rich transmembrane BMP regulator 1 (CRIM1), mRNA. | 3111 | GC-U1217 |
| CST11 | NM_130794.2 | Human | Homo sapiens cystatin 11 (CST11), transcript variant 1, mRNA. | 417 | GC-T3222 |
| CST11 | NM_080830.3 | Human | Homo sapiens cystatin 11 (CST11), transcript variant 2, mRNA. | 312 | GC-H0931 |
| CST2 | NM_001322.3 | Human | Homo sapiens cystatin SA (CST2), mRNA. | 426 | GC-Z2898 |
| CST3 | NM_001288614.1 | Human | Homo sapiens cystatin C (CST3), transcript variant 2, mRNA. | 441 | GC-F0113 |
| CST4 | NM_001899.3 | Human | Homo sapiens cystatin S (CST4), mRNA. | 426 | GC-F0420 |
| CST6 | NM_001323.4 | Human | Homo sapiens cystatin E/M (CST6), mRNA. | 450 | GC-M0688 |
| CST7 | NM_003650.4 | Human | Homo sapiens cystatin F (CST7), mRNA. | 438 | GC-U0145 |
| CST8 | NM_001281730.2 | Human | Homo sapiens cystatin 8 (CST8), transcript variant 2, mRNA. | 429 | GC-W0217 |
| CST9 | NM_001008693.3 | Human | Homo sapiens cystatin 9 (CST9), mRNA. | 480 | GC-H3350 |
| CST9L | NM_080610.3 | Human | Homo sapiens cystatin 9 like (CST9L), mRNA. | 444 | GC-T3229 |
| CSTA | NM_005213.4 | Human | Homo sapiens cystatin A (CSTA), mRNA. | 297 | GC-F0405 |
| CSTB | NM_000100.4 | Human | Homo sapiens cystatin B (CSTB), mRNA. | 297 | GC-F0136 |
| CSTL1 | NM_138283.1 | Human | Homo sapiens cystatin like 1 (CSTL1), mRNA. | 438 | GC-T3228 |
| FETUB | NM_014375.3 | Human | Homo sapiens fetuin B (FETUB), transcript variant 1, mRNA. | 1149 | GC-I0029 |
| GPC3 | NM_004484.4 | Human | Homo sapiens glypican 3 (GPC3), transcript variant 2, mRNA. | 1743 | GC-I0391 |
| GPC3 | NM_001164617.2 | Human | Homo sapiens glypican 3 (GPC3), transcript variant 1, mRNA. | 1812 | GC-Z7351 |
| GPC3 | NM_001164618.2 | Human | Homo sapiens glypican 3 (GPC3), transcript variant 3, mRNA. | 1695 | GC-Z7352 |
| GPC3 | NM_001164619.2 | Human | Homo sapiens glypican 3 (GPC3), transcript variant 4, mRNA. | 1581 | GC-Z7353 |
| GPX1 | NM_000581.4 | Human | Homo sapiens glutathione peroxidase 1 (GPX1), transcript variant 1, mRNA. | 612 | GC-Z2571 |
| GPX1 | NM_201397.3 | Human | Homo sapiens glutathione peroxidase 1 (GPX1), transcript variant 2, mRNA. | 297 | GC-Z3958 |
| HMSD | NM_001123366.2 | Human | Homo sapiens histocompatibility minor serpin domain containing (HMSD), mRNA. | 420 | GC-H3031 |
| HRG | NM_000412.5 | Human | Homo sapiens histidine rich glycoprotein (HRG), mRNA. | 1578 | GC-G0140 |
| HSPA5 | NM_005347.5 | Human | Homo sapiens heat shock protein family A (Hsp70) member 5 (HSPA5), mRNA. | 1965 | GC-T3592 |
