简介
组蛋白修饰是指组蛋白在相关酶作用下以动态方式发生甲基化、乙酰化、磷酸化、腺苷酸化、泛素化、ADP核糖基化等修饰的过程。组蛋白修饰酶包括：控制乙酰化的组蛋白乙酰转移酶HAT和组蛋白去乙酰化酶HDAC；甲基化的组蛋白甲基转移酶HMTs/KMTs、蛋白精氨酸甲基转移酶PRMTs、赖氨酸去甲基酶KDMs；泛素化的组蛋白泛素连接酶和去泛素化酶。组蛋白修饰是表观遗传学的主要形式之一，在遗传表达和表型调控中起着重要作用。例如，组蛋白修饰对神经系统相关基因表达有促进或抑制作用，而神经系统相关基因参与神经系统的正常功能、适应性调节和神经退行性疾病的发生，组蛋白修饰类型不同，作用不同。
套装信息
| 货号 | 物种 | 基因数 | 载体 | 载体类型 | 价格 |
|---|---|---|---|---|---|
| OC-HHM-M02 | Human | 107 | pReceiver-M02 | Expression-ready Non-viral | Inquire |
| OC-HHM-M35 | Human | 107 | pReceiver-M35 | Expression-ready Non-viral | Inquire |
| OC-HHM-M98 | Human | 107 | pReceiver-M98 | Expression-ready Non-viral | Inquire |
| OC-HHM-Lv105 | Human | 107 | pReceiver-Lv105 | Expression-ready Non-viral | Inquire |
| OC-HHM-Lv242 | Human | 107 | pReceiver-Lv242 | Expression-ready Lentiviral | Inquire |
| OC-HHM-GC | Human | 107 | pDONR™ Vector | Gateway shuttle | Inquire |
克隆列表
表格仅包含克隆套装部分内容，如需更多信息请通过电话（4006-020-200）或邮件（sales@igenebio.com）联系我们。
| Symbol | NCBI注册号 | 物种 | 基因描述 | ORF length(bp) | 产品ID |
| HDAC9 | NM_014707.4 | Human | Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 3, mRNA. | 1773 | GC-E0013 |
| DOT1L | NM_032482.3 | Human | Homo sapiens DOT1 like histone lysine methyltransferase (DOT1L), mRNA. | 4614 | GC-E0567 |
| HAT1 | NM_003642.3 | Human | Homo sapiens histone acetyltransferase 1 (HAT1), transcript variant 1, mRNA. | 1260 | GC-I0105 |
| HDAC1 | NM_004964.3 | Human | Homo sapiens histone deacetylase 1 (HDAC1), mRNA. | 1449 | GC-I0488 |
| KAT7 | NM_007067.4 | Human | Homo sapiens lysine acetyltransferase 7 (KAT7), transcript variant 1, mRNA. | 1836 | GC-T0265 |
| HDAC3 | NM_003883.4 | Human | Homo sapiens histone deacetylase 3 (HDAC3), transcript variant 2, mRNA. | 1287 | GC-T1848 |
| SIRT2 | NM_012237.4 | Human | Homo sapiens sirtuin 2 (SIRT2), transcript variant 1, mRNA. | 1170 | GC-T1930 |
| HDAC11 | NM_024827.4 | Human | Homo sapiens histone deacetylase 11 (HDAC11), transcript variant 1, mRNA. | 1044 | GC-T2114 |
| SETD7 | NM_030648.4 | Human | Homo sapiens SET domain containing 7, histone lysine methyltransferase (SETD7), transcript variant 1, mRNA. | 1101 | GC-T3450 |
| HDAC10 | NM_032019.6 | Human | Homo sapiens histone deacetylase 10 (HDAC10), transcript variant 1, mRNA. | 2010 | GC-T3601 |
| SUV39H1 | NM_003173.4 | Human | Homo sapiens SUV39H1 histone lysine methyltransferase (SUV39H1), transcript variant 2, mRNA. | 1239 | GC-U1202 |
| HDAC4 | NM_006037.4 | Human | Homo sapiens histone deacetylase 4 (HDAC4), transcript variant 2, mRNA. | 3255 | GC-U1371 |
| HDAC6 | NM_001321230.2 | Human | Homo sapiens histone deacetylase 6 (HDAC6), transcript variant 7, mRNA. | 441 | GC-V0819 |
| HDAC7 | NM_001098416.4 | Human | Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 4, mRNA. | 2865 | GC-Z1602 |
| HDAC5 | NM_001015053.2 | Human | Homo sapiens histone deacetylase 5 (HDAC5), transcript variant 3, mRNA. | 3372 | GC-Z4127 |
| HDAC7 | NM_015401.5 | Human | Homo sapiens histone deacetylase 7 (HDAC7), transcript variant 1, mRNA. | 2976 | GC-Z4621 |
| HDAC9 | NM_058176.2 | Human | Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 1, mRNA. | 3036 | GC-E2449 |
| HDAC9 | NM_178425.4 | Human | Homo sapiens histone deacetylase 9 (HDAC9), transcript variant 5, mRNA. | 3210 | GC-E2498 |
| SIRT2 | NM_030593.3 | Human | Homo sapiens sirtuin 2 (SIRT2), transcript variant 2, mRNA. | 1059 | GC-T3000 |
| EDF1 | NM_003792.4 | Human | Homo sapiens endothelial differentiation related factor 1 (EDF1), transcript variant alpha, mRNA. | 447 | GC-U0296 |
| ELP3 | NM_018091.6 | Human | Homo sapiens elongator acetyltransferase complex subunit 3 (ELP3), transcript variant 1, mRNA. | 1644 | GC-V0251 |
| OGA | NM_012215.5 | Human | Homo sapiens O-GlcNAcase (OGA), transcript variant 1, mRNA. | 2751 | GC-U1247 |
| CDY1 | NM_170723.2 | Human | Homo sapiens chromodomain Y-linked 1 (CDY1), transcript variant 1, mRNA. | 1623 | GC-Z4039 |
| CDYL | NM_004824.4 | Human | Homo sapiens chromodomain Y like (CDYL), transcript variant 1, mRNA. | 1635 | GC-Z1307 |
| CLOCK | NM_001267843.2 | Human | Homo sapiens clock circadian regulator (CLOCK), transcript variant 1, mRNA. | 2541 | GC-U0240 |
| ELP4 | NM_019040.5 | Human | Homo sapiens elongator acetyltransferase complex subunit 4 (ELP4), transcript variant 1, mRNA. | 1275 | GC-T1173 |
| GTF3C4 | NM_012204.4 | Human | Homo sapiens general transcription factor IIIC subunit 4 (GTF3C4), transcript variant 1, mRNA. | 2469 | GC-U0508 |
| NCOA3 | NM_006534.4 | Human | Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 2, mRNA. | 4263 | GC-Z3016 |
| NCOA3 | NM_181659.3 | Human | Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 1, mRNA. | 4275 | GC-Z5301 |
| USP22 | NM_015276.2 | Human | Homo sapiens ubiquitin specific peptidase 22 (USP22), mRNA. | 1578 | GC-H1929 |
| MTA2 | NM_004739.4 | Human | Homo sapiens metastasis associated 1 family member 2 (MTA2), transcript variant 1, mRNA. | 2007 | GC-U1472 |
| EZH1 | NM_001991.5 | Human | Homo sapiens enhancer of zeste 1 polycomb repressive complex 2 subunit (EZH1), transcript variant 1, mRNA. | 2244 | GC-M0269 |
| EZH2 | NM_004456.5 | Human | Homo sapiens enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), transcript variant 1, mRNA. | 2256 | GC-Z0388 |
| EZH2 | NM_152998.3 | Human | Homo sapiens enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), transcript variant 2, mRNA. | 2124 | GC-Z5167 |
| PRDM7 | NM_001098173.2 | Human | Homo sapiens PR/SET domain 7 (PRDM7), mRNA. | 1479 | GC-H1723 |
| KMT5B | NM_016028.4 | Human | Homo sapiens lysine methyltransferase 5B (KMT5B), transcript variant 2, mRNA. | 1182 | GC-Z4641 |
| KMT5B | NM_017635.5 | Human | Homo sapiens lysine methyltransferase 5B (KMT5B), transcript variant 1, mRNA. | 2658 | GC-Z4681 |
| KMT5C | NM_032701.4 | Human | Homo sapiens lysine methyltransferase 5C (KMT5C), mRNA. | 1389 | GC-Z1256 |
| NSD2 | NM_133335.4 | Human | Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 3, mRNA. | 4098 | GC-W0268 |
| NSD2 | NM_007331.2 | Human | Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 8, mRNA. | 1890 | GC-X0368 |
| NSD2 | NM_133334.2 | Human | Homo sapiens nuclear receptor binding SET domain protein 2 (NSD2), transcript variant 7, mRNA. | 1944 | GC-Z5057 |
| NSD3 | NM_023034.2 | Human | Homo sapiens nuclear receptor binding SET domain protein 3 (NSD3), transcript variant long, mRNA. | 4314 | GC-V1657 |
| NSD3 | NM_017778.3 | Human | Homo sapiens nuclear receptor binding SET domain protein 3 (NSD3), transcript variant short, mRNA. | 1938 | GC-X0597 |
| JMJD6 | NM_015167.3 | Human | Homo sapiens jumonji domain containing 6, arginine demethylase and lysine hydroxylase (JMJD6), transcript variant 2, mRNA. | 1212 | GC-E2113 |
| SUV39H2 | NM_001193426.2 | Human | Homo sapiens SUV39H2 histone lysine methyltransferase (SUV39H2), transcript variant 4, mRNA. | 693 | GC-T7836 |
| PRMT5 | NM_006109.5 | Human | Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 1, mRNA. | 1914 | GC-V1247 |
| KDM1A | NM_001009999.3 | Human | Homo sapiens lysine demethylase 1A (KDM1A), transcript variant 1, mRNA. | 2631 | GC-E2594 |
| KDM4C | NM_001146695.4 | Human | Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 3, mRNA. | 2442 | GC-Z7106 |
| KDM4C | NM_001146696.2 | Human | Homo sapiens lysine demethylase 4C (KDM4C), transcript variant 4, mRNA. | 2508 | GC-H4294 |
| KDM4E | NM_001161630.1 | Human | Homo sapiens lysine demethylase 4E (KDM4E), mRNA. | 1521 | GC-H4383 |
