简介
免疫肿瘤学（Immuno-oncology）是研究肿瘤与免疫系统相互作用的科学领域，揭示了肿瘤如何逃避免疫系统的监视和清除，以及如何利用免疫系统的机制促进其生长和扩散。以免疫肿瘤学为理论基础发展的癌症免疫疗法，是一种革命性的治疗方式，它通过激活或增强患者自身的免疫系统来识别和消灭癌细胞，与传统的癌症治疗手段如手术、放疗和化疗有本质的不同。癌症免疫疗法的形式多种多样，包括靶向抗体、癌症疫苗、T细胞转移疗法、病毒疗法、免疫检查点抑制剂、细胞因子和免疫佐剂等。
应用实例
免疫肿瘤学克隆套装可以配合GSRA技术对与目的蛋白相互作用的各种跨膜或分泌蛋白进行高通量筛选。Genome-scale receptor array （GSRA）是陈列平教授团队发明的一套半自动基因表达和检测系统，用以快速检测蛋白与蛋白之间的相互作用。本克隆套装助力多项研究成果：筛选 LAG-3 的配体蛋白，揭示了该 LAG-3-FGL1 通路在肿瘤免疫和治疗的作用[1]； 证明 Siglec-15 在体外和体内抑制抗原特异性 T 细胞反应，可以作为癌症免疫治疗的潜在靶点[2]；鉴定IGFBP7作为 CD97的配体，并证明IGFBP7-CD97相互作用会导致肿瘤脉管系统异常[3]；发现CD8的新功能，其通过与PILRα 的相互作用维持 CD8+ T细胞静止[4]。
Reference
- Wang, F., et al., Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. Cell, 2018
- Wang J, Sun J, Liu L N, et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature medicine, 2019
- Sun Y, Chen W, Torphy R J, et al. Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science Translational Medicine, 2021
- Zheng, L., et al., The CD8α-PILRα interaction maintains CD8+ T cell quiescence. Science, 2022
套装信息
| 货号 | 物种 | 基因数 | 载体 | 载体类型 | 价格 |
|---|---|---|---|---|---|
| OC-HIO-M02 | Human | 6592 | pReceiver-M02 | Expression-ready Non-viral | Inquire |
| OC-HIO-M35 | Human | 6592 | pReceiver-M35 | Expression-ready Non-viral | Inquire |
| OC-HIO-M98 | Human | 6592 | pReceiver-M98 | Expression-ready Non-viral | Inquire |
| OC-HIO-Lv105 | Human | 6592 | pReceiver-Lv105 | Expression-ready Non-viral | Inquire |
| OC-HIO-Lv242 | Human | 6592 | pReceiver-Lv242 | Expression-ready Lentiviral | Inquire |
| OC-HIO-GC | Human | 6592 | pDONR™ Vector | Gateway shuttle | Inquire |
克隆列表
表格仅包含克隆套装部分内容，如需更多信息请通过电话（4006-020-200）或邮件（sales@igenebio.com）联系我们。
| Symbol | NCBI注册号 | 物种 | 基因描述 | ORF length(bp) | 产品ID |
| TNFRSF9 | NM_001561.6 | Human | Homo sapiens TNF receptor superfamily member 9 (TNFRSF9), mRNA. | 768 | GC-A0225 |
| A1BG | NM_130786.4 | Human | Homo sapiens alpha-1-B glycoprotein (A1BG), mRNA. | 1488 | GC-T3535 |
| A2M | NM_000014.5 | Human | Homo sapiens alpha-2-macroglobulin (A2M), transcript variant 1, mRNA. | 4425 | GC-A3521 |
| A2ML1 | NM_144670.6 | Human | Homo sapiens alpha-2-macroglobulin like 1 (A2ML1), transcript variant 1, mRNA. | 4365 | GC-D0701 |
| A4GALT | NM_017436.7 | Human | Homo sapiens alpha 1,4-galactosyltransferase (P blood group) (A4GALT), transcript variant 1, mRNA. | 1062 | GC-U0876 |
| A4GNT | NM_016161.3 | Human | Homo sapiens alpha-1,4-N-acetylglucosaminyltransferase (A4GNT), mRNA. | 1023 | GC-U0796 |
| AAAS | NM_015665.6 | Human | Homo sapiens aladin WD repeat nucleoporin (AAAS), transcript variant 1, mRNA. | 1641 | GC-V0141 |
| AADAC | NM_001086.3 | Human | Homo sapiens arylacetamide deacetylase (AADAC), mRNA. | 1200 | GC-A4273 |
| ABCA1 | NM_005502.4 | Human | Homo sapiens ATP binding cassette subfamily A member 1 (ABCA1), mRNA. | 6786 | GC-A4304 |
| ABCA4 | NM_000350.2 | Human | Homo sapiens ATP binding cassette subfamily A member 4 (ABCA4), mRNA. | 6822 | GC-Q0446 |
| ABCA5 | NM_018672.5 | Human | Homo sapiens ATP binding cassette subfamily A member 5 (ABCA5), transcript variant 1, mRNA. | 4929 | GC-H4609 |
| ABCA6 | NM_080284.3 | Human | Homo sapiens ATP binding cassette subfamily A member 6 (ABCA6), mRNA. | 4854 | GC-I1895 |
| ABCA8 | NM_007168.4 | Human | Homo sapiens ATP binding cassette subfamily A member 8 (ABCA8), transcript variant 2, mRNA. | 4746 | GC-T0048 |
| ABCB1 | NM_000927.5 | Human | Homo sapiens ATP binding cassette subfamily B member 1 (ABCB1), transcript variant 3, mRNA. | 3843 | GC-E2266 |
| ABCB1 | NM_001348945.2 | Human | Homo sapiens ATP binding cassette subfamily B member 1 (ABCB1), transcript variant 1, mRNA. | 4053 | GC-E3923 |
| ABCB11 | NM_003742.201 | Human | Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA. Codon-optimized for Homo sapiens. | 3966 | GC-X1007 |
| ABCB11 | NM_003742.4 | Human | Homo sapiens ATP binding cassette subfamily B member 11 (ABCB11), mRNA. | 3966 | GC-H5308 |
| ABCB4 | NM_000443.4 | Human | Homo sapiens ATP binding cassette subfamily B member 4 (ABCB4), transcript variant A, mRNA. | 3840 | GC-G0814 |
| ABCB4 | NM_018850.3 | Human | Homo sapiens ATP binding cassette subfamily B member 4 (ABCB4), transcript variant C, mRNA. | 3699 | GC-Z4744 |
| ABCB5 | NM_178559.6 | Human | Homo sapiens ATP binding cassette subfamily B member 5 (ABCB5), transcript variant 2, mRNA. | 2439 | GC-E2036 |
| ABCB6 | NM_005689.4 | Human | Homo sapiens ATP binding cassette subfamily B member 6 (Langereis blood group) (ABCB6), transcript variant 1, mRNA. | 2529 | GC-T1895 |
| ABCB7 | NM_001271696.3 | Human | Homo sapiens ATP binding cassette subfamily B member 7 (ABCB7), transcript variant 2, mRNA; nuclear gene for mitochondrial product. | 2259 | GC-Y5172 |
| ABCB7 | NM_004299.6 | Human | Homo sapiens ATP binding cassette subfamily B member 7 (ABCB7), transcript variant 1, mRNA; nuclear gene for mitochondrial product. | 2262 | GC-Y2039 |
| ABCB8 | NM_007188.5 | Human | Homo sapiens ATP binding cassette subfamily B member 8 (ABCB8), transcript variant 2, mRNA; nuclear gene for mitochondrial product. | 2157 | GC-U0894 |
| ABCB9 | NM_001243014.2 | Human | Homo sapiens ATP binding cassette subfamily B member 9 (ABCB9), transcript variant 5, mRNA. | 2046 | GC-I0755 |
| ABCB9 | NM_019625.4 | Human | Homo sapiens ATP binding cassette subfamily B member 9 (ABCB9), transcript variant 1, mRNA. | 2301 | GC-T0728 |
| ABCC1 | NM_004996.4 | Human | Homo sapiens ATP binding cassette subfamily C member 1 (ABCC1), mRNA. | 4596 | GC-Z4479 |
| ABCC10 | NM_033450.3 | Human | Homo sapiens ATP binding cassette subfamily C member 10 (ABCC10), transcript variant MRP7A, mRNA. | 4395 | GC-E2232 |
| ABCC11 | NM_033151.4 | Human | Homo sapiens ATP binding cassette subfamily C member 11 (ABCC11), transcript variant 2, mRNA. | 4149 | GC-W1207 |
| ABCC2 | NM_000392.4 | Human | Homo sapiens ATP binding cassette subfamily C member 2 (ABCC2), mRNA. | 4638 | GC-Q0603 |
| ABCC2 | NM_000392.5 | Human | Homo sapiens ATP binding cassette subfamily C member 2 (ABCC2), mRNA. | 4638 | GC-A8900 |
| ABCC4 | NM_001105515.3 | Human | Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 2, mRNA. | 2580 | GC-T9124 |
| ABCC4 | NM_005845.5 | Human | Homo sapiens ATP binding cassette subfamily C member 4 (ABCC4), transcript variant 1, mRNA. | 3978 | GC-T0262 |
| ABCC8 | NM_000352.6 | Human | Homo sapiens ATP binding cassette subfamily C member 8 (ABCC8), transcript variant 2, mRNA. | 4746 | GC-Y4894 |
| ABCD1 | NM_000033.4 | Human | Homo sapiens ATP binding cassette subfamily D member 1 (ABCD1), mRNA. | 2238 | GC-C0357 |
| ABCD3 | NM_001122674.2 | Human | Homo sapiens ATP binding cassette subfamily D member 3 (ABCD3), transcript variant 2, mRNA. | 711 | GC-T7842 |
| ABCG1 | NM_004915.4 | Human | Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 4, mRNA. | 2037 | GC-Z0825 |
| ABCG1 | NM_016818.3 | Human | Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 2, mRNA. | 2001 | GC-Z3287 |
| ABCG1 | NM_207628.1 | Human | Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1), transcript variant 6, mRNA. | 1935 | GC-Z8089 |
| ABCG2 | NM_004827.3 | Human | Homo sapiens ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2), transcript variant 1, mRNA. | 1968 | GC-Q0668 |
| ABCG4 | NM_022169.5 | Human | Homo sapiens ATP binding cassette subfamily G member 4 (ABCG4), transcript variant 1, mRNA. | 1941 | GC-Z1538 |
| ABHD1 | NM_032604.4 | Human | Homo sapiens abhydrolase domain containing 1 (ABHD1), mRNA. | 1218 | GC-W2844 |
| ABHD12 | NM_015600.5 | Human | Homo sapiens abhydrolase domain containing 12, lysophospholipase (ABHD12), transcript variant 2, mRNA. | 1215 | GC-T2637 |
| ABHD13 | NM_032859.3 | Human | Homo sapiens abhydrolase domain containing 13 (ABHD13), mRNA. | 1014 | GC-T8787 |
| ABHD17A | NM_001130111.2 | Human | Homo sapiens abhydrolase domain containing 17A, depalmitoylase (ABHD17A), transcript variant 2, mRNA. | 933 | GC-Z6406 |
| ABHD17A | NM_031213.4 | Human | Homo sapiens abhydrolase domain containing 17A, depalmitoylase (ABHD17A), transcript variant 1, mRNA. | 1086 | GC-Z9629 |
| ABHD2 | NM_152924.5 | Human | Homo sapiens abhydrolase domain containing 2, acylglycerol lipase (ABHD2), transcript variant 2, mRNA. | 1278 | GC-G0334 |
| ABHD3 | NM_138340.5 | Human | Homo sapiens abhydrolase domain containing 3, phospholipase (ABHD3), transcript variant 1, mRNA. | 1230 | GC-H4722 |
| ABHD6 | NM_001320126.2 | Human | Homo sapiens abhydrolase domain containing 6, acylglycerol lipase (ABHD6), transcript variant 1, mRNA. | 1014 | GC-V0321 |
| ABI1 | NM_005470.4 | Human | Homo sapiens abl interactor 1 (ABI1), transcript variant 1, mRNA. | 1527 | GC-Z4495 |
