基因组编辑工具（CRISPR & TALEN）

• Duron, D.I., et al. (2024). Inhibiting spinal cord-specific hsp90 isoforms reveals a novel strategy to improve the therapeutic index of opioid treatment. Sci Rep. DOI: 10.1038/s41598-024-65637-6 [sgRNA/Cas9 all-in-one expression clones targeting Hsp90α, Hsp90β and Grp94]
• Zhou, Y., et al. (2024). GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma. Theranostics. DOI: 10.7150/thno.92646 [sgRNA/Cas9 all-in-one expression clone targeting GPAT3]
• Yu, T., et al. (2024). NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation. Cell Rep. DOI: 10.1016/j.celrep.2024.114070 [Cas9 nuclease expression vector]
• Roy, S.K., et al. (2024). Clinical significance of PNO1 as a novel biomarker and therapeutic target of hepatocellular carcinoma. J Cell Mol Med. DOI: 10.1111/jcmm.18295 [GeneHero™ Scrambled sgRNA control for pCRISPR-LvSG03; GeneHero™ 3×sgRNA lentiviral expression clone targeting PNO1; Cas9 nuclease lentiviral expression clones]
• Jiang, Y., et al. (2024). Targeting the Cdc2‐like kinase 2 for overcoming platinum resistance in ovarian cancer. MedComm (2020). DOI: 10.1002/mco2.537 [OMICSLINK™ Human CLK2 ORF expression clone, Cat. No.EX-X0960-Lv121; GeneHero™ sgRNA clones targeting Human CLK2, Cat. No.HCP001098‐CG01‐3‐10]
• Rupasinghe, M., et al. (2024). PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency. EMBO Rep. DOI: 10.1038/s44319-024-00083-z [GeneHero™ mouse ROSA26 safe harbor gene knock-in kit, Cat. No. SH054]
• Xue Zhang, et al. 2024.Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity. Nat Commun.DOI:10.1038/s41467-024-44778-2[GeneHero™ CRISPR Products and Services (Cat. No.pCRISPR-CG01-sgBmal1-a; pCRISPR-CG01-sgBmal1-b;pCRISPR-CG01-sgBmal1-c;pCRISPR-CG01-scramble)]
• Sherif Rashad, et al. 2024.Translational response to mitochondrial stresses is orchestrated by tRNA modifications. bioRxiv.DOI:10.1101/2024.02.14.580389[T7 endonuclease I assay kit]

• Helen R. Maunsell, et al. 2023.Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti. J Neurosci.DOI:10.1523/JNEUROSCI.2141-22.2023[GeneHero™ TALEN Services]
• Liu, W., et al. (2023). MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer. Cell Mol Biol Lett. doi: 10.1186/s11658-023-00487-0 [OMICSLINK™ Human MCCC2 ORF expression clone; GeneHero™ sgRNA clones targeting Human MCCC2]
• Dorgham, M.G., et al. (2023). m6A regulates breast cancer proliferation and migration through stage-dependent changes in Epithelial to Mesenchymal Transition gene expression. Front Oncol. doi: 10.3389/fonc.2023.1268977 [GeneHero™ human Cas9 all-in-one expression clone targeting METTL3; GeneHero™ Scrambled sgRNA control for pCRISPR-CG01]
• Xu, L., et al. (2023). Generation of Rh D‐negative blood using CRISPR/Cas9. Cell Prolif. doi: 10.1111/cpr.13486 [GeneHero™ Cas9 expressing vector; GeneHero™ AAVS1 Cas9 knock-in clone]
• Itson-Zoske, B., et al. (2023). Selective RNAi-silencing of Schwann cell Piezo1 alleviates mechanical hypersensitization following peripheral nerve injury. Res Sq. doi: 10.21203/rs.3.rs-3405016/v1 [GeneHero™ Cas9 expressing stable cell line]
• Grzelak, C.A., et al. (2023). Elimination of 4T1 Mammary Tumor Cells by BALB/cBy UBC-GFP Transgenics following Stable Inheritance of the H-2b MHC Allele. Immunohorizons. doi: 10.4049/immunohorizons.2200101 [Genome-TALER™ Mouse ROSA26 Safe Harbor ORF clone]
• Liesenhoff, C., et al. (2023). Endogenous Galectin-1 Modulates Cell Biological Properties of Immortalized Retinal Pigment Epithelial Cells In Vitro. Int J Mol Sci. doi: 10.3390/ijms241612635 [GeneHero™ human Cas9 all-in-one expression clone targeting LGALS1]
• Schuler, B., et al. (2023). Host Lipid Transport Protein ORP1 Is Necessary for Coxiella burnetii Growth and Vacuole Expansion in Macrophages. mSphere doi: 10.1128/msphere.00104-23 [GeneHero™ sgRNA expression clones targeting OSBPL1A]
• Pal, D., et al. (2023). H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function. Nat Struct Mol Biol doi: 10.1038/s41594-023-01016-5 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit]
• Naoki, I-T., et al. (2023). The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling. Cells doi: 10.3390/cells12131696 [GeneHero™ sgRNA clones targeting mouse Blk; GeneHero™ sgRNA clones targeting mouse Scr]
• Talic, E-S., et al. (2023). RNA Methyltransferase METTL16’s Protein Domains Have Differential Functional Effects on Cell Processes. Curr Issues Mol Biol doi: 10.3390/cimb45070346 [GeneHero™ sgRNA control; GeneHero™ METTL16 Cas9-expressing clone]
• Wan, Y., et al. (2023). Nonmonotone invasion landscape by noise-aware control of metastasis activator levels. Nat Chem Biol doi: 10.1038/s41589-023-01344-z [Genome-TALER™ human AAVS1 safe harbor gene knock-in kits and clones]
• Schwarz, A.M., et al. (2023). Terpenes from Cannabis sativa Induce Antinociception in Mouse Chronic Neuropathic Pain via Activation of Spinal Cord Adenosine A2A Receptors. bioRxiv doi: 10.1101/2023.03.28.534594 [GeneHero™ Cas9-expressing clone]
• Li, C., et al. (2023). SUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation. J Proteome Res doi: 10.1021/acs.jproteome.2c00557 [GeneHero™ PIAS1、PIAS2、PIAS3、PIAS4 sgRNA clones and negative control]
• Qin, Q., et al. (2023). CNTNAP4 signaling regulates osteosarcoma disease progression. NPJ Precis Oncol doi: 10.1038/s41698-022-00344-x [T7 Endonuclease I Assay Kit; SuperCut™ Nuclease]
• Lin, P., et al. (2023). TRAF6 regulates the abundance of RIPK1 and inhibits the RIPK1/RIPK3/MLKL necroptosis signaling pathway and affects the progression of colorectal cancer. Cell Death Dis doi: 10.1038/s41419-022-05524-y [GeneHero™ Cas9-expressing clone]
• Atobatele, A.G., et al. (2023). Canonical and truncated transglutaminase-2 regulate mucin-1 expression and androgen independency in prostate cancer cell lines. Cell Death Dis doi: 10.1038/s41419-023-05818-9 [GeneHero™ TGM2 sgRNA clones]

• Martin-Gallausiaux, C., et al. (2022). Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway. Gut Microbes doi: 10.1080/19490976.2022.2110639 [GeneHero™ sgRNA clones targeting TIFA、TRAF6 、 MYD88]
• Liu, S., et al. (2022). DNA repair protein RAD52 is required for protecting G-quadruplexes in mammalian cells. J Biol Chem doi: 10.1016/j.jbc.2022.102770 [GeneHero™ RAD52/FANCJ sgRNA clones]
• Ren, L., et al. (2022). Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains. JCI Insight doi: 10.1172/jci.insight.162602 [GeneHero™ sgRNA clones targeting Adcy1]
• Chupradit, K., et al. (2022). Validation of Promoters and Codon Optimization on CRISPR/Cas9-Engineered Jurkat Cells Stably Expressing αRep4E3 for Interfering with HIV-1 Replication. Int J Mol Sci doi: 10.3390/ijms232315049 [DC-DON-SH01 expression vector for restriction enzyme cloning]
• Zhang, D.Y., et al. (2022). Whole Exome Sequencing Identifies PHF14 Mutations in Neurocytoma and Predicts Responsivity to the PDGFR Inhibitor Sunitinib. Biomedicines doi: 10.3390/biomedicines10112842 [sgRNA control]
• Brooks, R., et al. (2022). Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis. Cell Rep doi: 10.1016/j.celrep.2022.111514 [BMAL1 gRNA]
• Han, S.T., et al. (2022). PUS7 deficiency in human patients causes profound neurodevelopmental phenotype by dysregulating protein translation. Molecular Genetics and Metabolism doi: 10.1016/j.ymgme.2022.01.103 [GeneHero™  HeLa Cas9-expressing stable cell line]
• Sánchez-Marco, J., et al. (2022). Thioredoxin Domain Containing 5 Suppression Elicits Serum Amyloid A-Containing High-Density Lipoproteins. Biomedicines doi: 10.3390/biomedicines10030709 [IndelCheck™ Insertion/deletion detection system]
• Asuthkar, S., et al. (2022). SMYD3 Promotes Cell Cycle Progression by Inducing Cyclin D3 Transcription and Stabilizing the Cyclin D1 Protein in Medulloblastoma. Cancers doi: 10.3390/cancers14071673 [GeneHero™ SMYD3 sgRNA clones]
• Zhang, L., et al. (2022). CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells. Molecular Cancer doi: 10.1186/s12943-022-01524-w [GeneHero™ sgRNA clones targeting CDK6]
• Kaneski, C.R., et al. (2022). Generation of an in vitro model for peripheral neuropathy in Fabry disease using CRISPR-Cas9 in the nociceptive dorsal root ganglion cell line 50B11. Molecular Genetics and Metabolism Reports doI; 10.1016/j.ymgmr.2022.100871 [GeneHero™ sgRNA clones targeting GLA]
• Wang, Y., et al. (2022). Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia. Cell Death & Disease doi: 10.1038/s41419-022-04873-y [IndelCheck™ Insertion/deletion detection system]
• Badrinath, S., et al. (2022). A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature doi: 10.1038/s41586-022-04772-4 [Genome-TALER™ mouse ROSA26 safe harbor gene knockin kit and donor]
• Domingo-Vidal. M., et al. (2022). Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers. Frontiers in Oncology doi: 10.3389/fonc.2022.906494 [GeneHero™ lentiviral sgRNA clones targeting SLC16A3]
• Tontonoz, P. and Kaeberlein, P. (2022). SIRT1 regulates sphingolipid metabolism and neural differentiation of mouse embryonic stem cells through c-Myc-SMPDL3B. eLife doi:  10.7554/eLife.67452  [GeneHero™ sgRNA clones targeting mSirt1]
• Zheng, W., et al. (2022). SIRT1 inactivation switches reactive astrocytes to an anti-inflammatory phenotype in CNS autoimmunity. The Journal of Clinical Investigation doi: 10.1172/JCI151803 [GeneHero™  Neuro2a Cas9-expressing stable cell line]

• Simkin, D., et al. (2021). Dyshomeostatic modulation of Ca2+-activated K+channels in a humanneuronal model of KCNQ2 encephalopathy. wLife doi: 10.7554/eLife.64434 [IndelCheck™ Insertion/deletion detection system]
• Hana, S., et al. (2021) Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice. Gene Therapy doi: 10.1038/s41434-021-00224-2 [GeneHero™  HeLa, Neuro2a Cas9-expressing stable cell lines]
• Lee, Y., et al. (2021). Time-of-day specificity ofanticancer drugs may bemediated by circadian regulation ofthecell cycle. Science Advances doi: 10.1126/sciadv.abd2645 [GeneHero™ sgRNA clones]
• Liu, S., et al. (2021). Barcoded oligonucleotides ligated on RNA amplified for multiplexed and parallel in situ analyses. Nucleic Acids Research doi: 10.1093/nar/gkab120 [GeneHero™  HeLa Cas9-expressing stable cell line]
• Li, X., et a. (2021). Enhancing Gene Editing Efficiency for Cells by CRISPR/Cas9 System-Loaded Multilayered Nanoparticles Assembled via Microfluidics. Chinese Journal of Chemical Engineering doi: 10.1016/j.cjche.2021.02.009 [GeneHero™ Cas9-expressing clone]
• Kwik, M., et al. (2021). Selective Activation of CNS and ReferencePPARGC1APromoters Is Associated with Distinct Gene Programs Relevantfor Neurodegenerative Diseases. International Journal of Molecular Sciences doi: 10.3390/ijms22073296 [GeneHero™ sgRNA clones]
• Huo, X., et al. (2021). MicroRNA-4325 Suppresses Cell Progression in Hepatocellular Carcinoma via GATA-Binding Protein 6. BioMed Research International doi: 10.1155/2021/6616982 [GeneHero™ sgRNA clones targeting GATA6]
• Monserrat, J., et al. (2021). Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability. Nature Cell Biology doi: 10.1038/s41556-021-00657-2 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit]
• Galula, J. C., et al. (2021). Comparable Accuracies of Nonstructural Protein 1- and EnvelopeProtein-Based Enzyme-Linked Immunosorbent Assays inDetecting Anti-Dengue Immunoglobulin G Antibodies. Diagnostics doi: 10.3390/diagnostics11050741 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit] (2021). Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons. Translational Psychiatry doi: 10.1038/s41398-021-01392-w [GeneHero™ donor clone]
• Kronenberg, J., et al. (2021). The tobacco phosphatidylethanolamine-binding protein NtFT4 simultaneously improves vitality, growth and protein yield in human cells. Biotechnology and Bioengineering doi: 10.1002/bit.27853 [GenomeTALER™ human AAVS1 safe harbor gene knockin kit]
• Woo, H-H. and Chambers, S.K. (2021). Regulation  of  closely  juxtaposed  protooncogene c-fms  and HMGXB3  gene expression by mRNA 3’end polymorphism in breast cancer cells. RNA doi: 10.1261/rna.078749.121 [GeneHero™ donor clone]
• Gozgit, J.M., et al. (2021). PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity. Cancer Cell doi: 10.1016/j.ccell.2021.06.018 [GeneHero™  CT26 Cas9-expressing stable cell line]
• Pons, B.J., et al. (2021). Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response. Cellular and Molecular Life Sciences doi: 10.1007/s00018-021-03902-x [GenomeTALER™ human AAVS1 safe harbor gene knockin kit]
• Pe~na-Hernandez, P., et al. (2021). BAZ2A-mediated repression via H3K14ac-markedenhancers promotes prostate cancer stem cells. EMBO Reports doi: 10.15252/embr.202153014 [GenomeCRISPR™ mouse ROSA26 BAZ2A safe harbor gene knockin clone]
• Chafe, S.C., et a. (2021). Genome-wide synthetic lethal screen unveils novel  CAIX-NFS1/xCT axis as a targetable vulnerability  in hypoxic solid tumors. Science Advances doi: 10.1126/sciadv.abj0364 [GeneHero™ sgRNA clones]
• Xia, L., et al. (2021). Multiplatform discovery and regulatory function analysis of structural variations in non-small cell lung carcinoma. Cell Reports doi: 10.1016/j.celrep.2021.109660 [GeneHero™ sgRNA and HDR donor clones]
• Dzakah, E.E., et al. (2021). Chlamydia trachomatis stimulation enhances HIV-1 susceptibility via the modulation of a member of the macrophage inflammatory proteins. Journal of Investigative Dermatology doi: 10.1016/j.jid.2021.09.020 [GeneHero™ lentiviral sgRNA clones]
• López-Royo, T., et al, (2021). Encapsulation of Large-Size Plasmids in PLGA Nanoparticles for Gene Editing: Comparison of Three Different Synthesis Methods. Nanomaterials 10.3390/nano11102723 [GenomeCRISPR™ safe harbor gene knockin clone]
• Stojkovska, I., et al. (2021). Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking. Neuron doi: 10.1016/j.neuron.2021.10.032 [IndelCheck™ Insertion/deletion detection system]
• Song, Y., et al. (2021). A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis. PLOS Pathogens doi: 10.1371/journal.ppat.1010141 [GeneHero™  A549 Cas9-expressing stable cell line]
• Szaflarski, W. , et al. (2021). Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity. Nucleic Acids Research doi: 10.1093/nar/gkab1231 [GeneHero™ sgRNA and HDR donor clones]

• Frendewey, D., et al. (2020). METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAS. United States Patent Application 20200002730 [GeneHero™ sgRNA clones targeting Lrp5]
• Zhang, L., et al. (2020). The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer. Molecular Cancer doi: 10.1186/s12943-019-1112-1 [GeneHero™ sgRNA clones targeting PIK3CA, PIK3CB]
• Chen, P., et al. (2020). High RhCG expression predicts poor survival and promotes migration and proliferation of gastric cancer via keeping intracellular alkaline. Experimental Cell Research doi: 10.1016/j.yexcr.2019.111740 [GeneHero™ sgRNA clone]
• López, S.M., et al. (2020). Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy. PLOS ONE doi: 10.1371/journal.pone.0228072 [GeneHero™ sgRNA clones, GenomeTALER™ TALEN clones, and donor clone targeting canine DMD]
• Joshi, A., et al. (2020). The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis. BMC Biology doi: 10.1186/s12915-020-0740-7 [GeneHero™ sgRNA clones targeting UMUC3]
• Li, C., et al. (2020). Quantitative SUMO proteomics identifies PIAS1 substrates involved in cell migration and motility, Nature Communications doi: 10.1038/s41467-020-14581-w [GeneHero™ sgRNA clones targeting PIAS]
• Phu, L., et al. (2020). Dynamic Regulation of Mitochondrial Import by the Ubiquitin System. Molecular Cell doi: 10.1016/j.molcel.2020.02.012 [Genome-TALER™ human AAVS1 safe harbor gene knockin kit]
• Stinger, R.N., et al. (2020). A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity. Molecular Brain doi: 10.1186/s13041-020-00577-6 [GeneHero™ sgRNA clones and donor clone]
• Rakvács, Z. (2020). Investigation of the human ABCB6 transporter. Ph.D. Thesis, Semmelweis University [IndelCheck™ Insertion/deletion detection system]
• Renema, P., et al. (2019). cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. American Journal of Physiology-Lung Cellular and Molecular Physiology doi: 10.1152/ajplung.00185.2019 [GeneHero™ sgRNA clones targeting Rat Casp1]
• Lin, C-L., et al. (2020). ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer. BMC Medical Genomics doi: 10.1186/s12920-020-0729-7 [GeneHero™ sgRNA clones]
• Meinhardt, G., et al. (2020). Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta . Proceedings of the National Academy of Scienes of the United States of America doi: 10.1073/pnas.2002630117 [GeneHero™ sgRNA clones targeting YAP]
• Nelson, J., et al. (2020). Impact of mRNA chemistry and manufacturing process on innate immune activation. Science Advances doi: 10.1126/sciadv.aaz6893 [GeneHero™ sgRNA clones targeting MAVS]
• Schweitzer, K.S., et al. (2020). IGSF3 mutation identified in patient with severe COPD alters cell function and motility. JCI insight doi: 10.1172/jci.insight.138101 [GeneHero™ sgRNA clones targeting Beas2B]
• Badaoui, M., et al. (2020). Vav3 Mediates Pseudomonas aeruginosa Adhesion to the Cystic Fibrosis Airway Epithelium. Cell Reports doi: 10.1016/j.celrep.2020.107842 [GeneHero™ leniviral particles expressing sgRNA clones targeting Vav3]
• Renema, P., et al. (2020). cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. American Journal of Physiology – Lung Cellular and Molecular Physiology doi: 10.1152/ajplung.00185.2019 [GeneHero™ sgRNA clones targeting caspase-1]
• Feng, Y.C., et al. (2020). c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Nature Communications doi: 10.1038/s41467-020-18735-8 [GeneHero™ CRISPRi sgRNA clones targeting MILIP]
• Wang, L., et al. (2020). Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. The ournal of Clinical Investigation doi: 10.1172/JCI130445 [GeneHero™ sgRNA clones targeting Arid1a]
• Chaudhari, H.G., et al. (2020). Evaluation of Homology-Independent CRISPR-Cas9Off-Target Assessment Methods. The CRISPR Journal doi: 10.1089/crispr.2020.0053 [GeneHero™  HEK293 Cas9-expressing stable cell line]
• Morleo, M., et al. (2020). Regulation of autophagosome biogenesis byOFD1-mediated selective autophagy. The EMBO Journal doi: 10.15252/embj.2020105120 [GeneHero™ sgRNA clones]

• Gürtler, S., et al. (2019). Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids doi: 10.1016/j.bbalip.2019.01.006 [GeneHero™ sgRNA clones targeting Taz1]
• Wang, Z., et al. (2019). DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork  collapse. The Journal of Biological Chemistry doi: 10.1074/jbc.RA118.005188 [GeneHero™ sgRNA clones targeting POLQ]
• Adams, J., et al. (2019). Autophagy–lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease. Scientific Reports doi: 10.1038/s41598-018-36379-z [GeneHero™ sgRNA clones targeting SNCA]
• Geng, Y., et al. (2019). PD-L1 on invasive fibroblasts drives fibrosis in a humanized model of idiopathic pulmonary fibrosis. JCI Insight [GeneHero™ sgRNA clone targeting CD274]
• Zheng, Y-L., et al. (2019). LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway. Theranostics doi: 10.7150/thno.28992 [GeneHero™ sgRNA clones targeting LINC01554]
• Pushpavathi, G., et al. (2019). CRISPR/Cas9 Editing of Glia Maturation Factor Regulates Mitochondrial Dynamics by Attenuation of the NRF2/HO-1 Dependent Ferritin Activation in Glial Cells. Journal of Neuroimmune Pharmacology doi: 10.1007/s11481-019-09833-6 [GeneHero™ lentiviral sgRNA clones]
• Zang, J., et al. (2019). Glucose drives growth factor-independent esophageal cancer proliferation viaphosphohistidine-FAK signaling. Cellular and Molecular Gastroenterology and Hepatology doi:10.1016/j.jcmgh.2019.02.009 [GeneHero™ sgRNA clones targeting PTK2]
• Zhang, D., et al. (2019). Chromogranin A regulates neuroblastoma proliferation and phenotype. Biology Open doi: 10.1242/bio.036566 [GeneHero™ sgRNA clones targeting CHGA]
• Ji, J., et al. (2019). FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX. Oxidative Medicine and Cellular Longevity doi: 10.1155/2019/3286928 [GeneHero™ sgRNA clones targeting FOXO1; IndelCheck™ Insertion/deletion detection system]
• Pradhan, A.K., et al. (2019). MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF. Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1819869116 [GeneHero™ sgRNA clones targeting MDA-7/IL-24]
• Iyer, K.S., et al. (2019).   BIOCOMPATIBLE DENDRONISED POLYMER AS A  NON – VIRAL TRANSFECTION AGENT. United States Patent Application 16/128,936 [Genome-TALER™ TALE-TF clone]
• Ghoshal, A., et al. (2019). Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis. Oncogene doi: 10.1038/s41388-019-0797-3 [GeneHero™ sgRNA clones targeting IGF2BP1]
• Pan, C., et al. (2019). Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance. Journal of Clinical INvestigation doi: 10.1172/JCI124550DS1 [GeneHero™ lentiviral sgRNA clones targeting IGF2BP1]
• Ramakrishnan, A. (2019). DISC1 is needed for the organization of cellular components at the immunological synapse. Ph.D. Thesis, University of Texas [GeneHero™ lentiviral sgRNA clones targeting DISC1]
• Sastri, M. (2019). PEPTIDES FOR ANGIOGENIC THERAPY. United States Patent Application 20190389922 [Human AAVS1 Safe Harbor knock-in kit]
• Wall, C.E., et al. (2019). PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin. Cell Reports doi: 10.1016/j.celrep.2019.10.130 [GeneHero™ sgRNA clones targeting PPEF2]
• Narimani, M., et al. (2019). Knockout Of BIRC5 Gene By CRISPR/Cas9 Induces Apoptosis And Inhibits Cell Proliferation In Leukemic Cell Lines, HL60 And KG1/. Blood and Lymphatic Cancer: Targets and Therapy doi: 10.2147/BLCTT.S230383 [GeneHero™ sgRNA clones]
• Masoudi, M., et al. (2010). A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine. Scientific Reports doi: 10.1038/s41598-019-55893-2 [IndelCheck™ Insertion or Deletion Detection System]
• Kang, K., et al. (2019). An improved Tet-on system in microRNA overexpression and CRISPR/Cas9-mediated gene editing. Journal of Animal Science and Biotechnology doi: 10.1186/s40104-019-0354-5 [T7 Endonuclease I]
• Turturro, S.B., et al. (2019). Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway. Breast Cancer Research and Treatment doi: 10.1007/s10549-019-05320-x [GeneHero™ sgRNA clones]
• Sussman, W., et al. (2019). BMAL1 controls glucose uptake through paired-homeodomain transcriptionfactor 4 in differentiated Caco-2 cells. American Journal of Physiology-Cell physiology doi: 10.1152/ajpcell.00058.2019 [GeneHero™ sgRNA clones targeting PAX4]
• Kulbay, M., et al. (2019). DNA fragmentation factor 40 expression in T cells confers sensibility to tributyltin-induced apoptosis. Toxicology doi: 10.1016/j.tox.2019.152255 [GeneHero™ sgRNA clones]
• Li, H., et al. (2019). PFN2a Suppresses C2C12 Myogenic Development by Inhibiting Proliferation and Promoting Apoptosis via the p53 Pathway. Cells doi: 10.3390/cells8090959 [GeneHero™ mouse ROSA26 safe harbor gene knockin kit]
• Barrow, M.A., et a. (2019). A functional role for the cancer disparity-linked genes, CRYβB2 and CRYβB2P1, in the promotion of breast cancer. Breast Cancer Research doi: 10.1186/s13058-019-1191-3 [GeneHero™ sgRNA clones]
• Kuo, T., et al. (2019). Identification of C2CD4A as a human diabetes susceptibility gene with a role in β cell insulin secretion. Proceedingsof the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1904311116 [GeneHero™ sgRNA clones targeting C2CD4A]
• Fujimoto, B.A., et al. (2019). The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells. American Journal of Physiology-Enocrinology and Metabolism doi: 0.1152/ajpendo.00109.2019 [GeneHero™ sgRNA clones]
• Yu, W., et al. (2019). Higher expression of SATB2 in hepatocellular carcinoma of African Americans determines more aggressive phenotypes than those of Caucasian Americans. Journal of Cellular and Molecular Medicine doi: 10.1111/jcmm.14652 [GeneHero™lentiviral CRISPR clones targeting SATB2]
• Gohari, I.M., et al. (2019). Effects of Claudin-1 on the Action of Clostridium perfringens Enterotoxin in Caco-2 Cells. Toxins doi: 10.3390/toxins11100582 [GeneHero™ CRISPR clones targeting Claudin-1]

• Kanda, Y., et al. (2018). TRPA1-dependent reversible opening of tight junction by natural compounds with an α,β-unsaturated moiety and capsaicin. Scientific Reports DOI: 10.1038/s41598-018-20526-7 [Genome-CRISP™ sgRNA clones targeting TRPA1]
• Chen, X., et al. (2018). A spliced form of CD44 expresses the unique glycan that is recognized by the prostate cancer specific antibody F77. Ocotarget DOI: 10.18632/oncotarget.23341 [Genome-CRISP™ CRISPR-Cas9 constructs]
• Maier, M., et al. (2018). The Role of Trio, a Rho Guanine Nucleotide Exchange Factor, in Glomerular Podocytes. International Journal of Molecular Sciences DOI: 10.3390/ijms19020479 [Genome-CRISP™  lentiviral clone expressing sgRNA targeting Trio]
• Sokhi, U.K., et al. (2018). Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models. Nature Communications DOI: 10.1038/s41467-018-03081-7 [HEK293T Cas9-expressing stable cell line]
• Zhao, D., et al. (2018). Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Molecular Cell DOI: 10.1016/j.molcel.2018.01.017 [HeLa, HEK293T and A549 Cas9-expressing stable cell lines]
• Norouzi-Barough, L., et al. (2018). Bioinformatics design of CRISPR guide RNA for genomic knockout of  ABCB1 gene. Biotech Health Sci. 2018 Feb; 4(3):e58783 [Genome-CRISP™  clones expressing sgRNA targeting ABCB1]
• Quadalti, C., et al. (2018). SURF1 knockout cloned pigs: Early onset of a severe lethal phenotype. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease DOI: 10.1016/j.bbadis.2018.03.021 [Genome-TALER™ clone targeted to SURF1]
• Raikwar, S.P., et al. (2018). Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer’s Disease Therapeutic Target. Molecular Neurobiology DOI: 10.1007/s12035-018-1068-y [Genome-CRISP™  lentiviral clones expressing sgRNA targeting GMF]
• Shen, J., et al. (2018). ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nature Medicine DOI: 10.1038/s41591-018-0012-z [Genome-CRISP™ lentiviral clones expressing sgRNA targeting ARID1A]
• Huang, H., et al. (2018). EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. Molecular Cell DOI: 10.1016/j.molcel.2018.04.011 [Genome-CRISP™  clones expressing sgRNA targeting EP300]
• Bezawork-Geleta, A., et al. (2018). Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints. Nature Communications DOI: 10.1038/s41467-018-04603-z [Genome-TALER™ clone targeted to SDHB]
• Dakhama, A. and Chu, H-W. (2018). The Use of CRISPR-Cas9 Technology to Reveal Important Aspects of Human Airway Biology. Type 2 Immunity doi: 10.1007/978-1-4939-7896-0_27 [Lentiviral CRISPR clones]
• Li, Y., et al. (2018). Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage, Nucleic Acids Research doi: 10.1093/nar/gky568 [Lentiviral CRISPR clones]
• Sharlati, L., et al. (2018). Disruption of SOX6 gene using CRISPR/Cas9 technology for gamma‐globin reactivation: An approach towards gene therapy of β‐thalassemia. Journal of Cellular Biochemistry doi: 10.1002/jcb.27253 [CRISPR clones]
• Suganuma, T., et al. (2018). MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism. Cell Reports doi: 10.1016/j.celrep.2018.07.013 [Genome-CRISP™  clone expressing sgRNA targeting MOCS2]
• Hulea, L., et al. (2018). Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. Cell Metabolism doi: 10.1016/j.cmet.2018.09.001 [GeneHero™  clones expressing sgRNAs targeting h4E-BP1, h4E-BP2, m4E-BP1, m4E-BP2]
• Seturuman, A., et al. (2018). BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion. Breast Cancer Research doi: 10.1186/s13058-018-1046-3 [GeneHero™  clone expressing sgRNA targetingBHLHE40]
• Raas, Q., et al. (2018). A microglial cell model for acyl-CoA oxidase 1 deficiency. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids doi: 10.1016/j.bbalip.2018.10.005 [GeneHero™  clone expressing sgRNA]
• Jakimo, N., et al. (2018). Chimeric DNA:RNA Guide for High Accuracy Cas9 Genome Editing. United States Patent Application 20180282722 [GeneHero™  HEK293 Cas9-expressing stable cell line]
• Wei, N., et al. (2018). Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. Oncogene doi: 10.1038/s41388-018-0547-y [GeneHero™ clone expressing sgRNA targeting STAT3]
• Gulyaeva, O., et al. (2018). Sox9-Meis1 Inactivation Is Required for Adipogenesis, Advancing Pref-1+ to PDGFRα+ Cells. Cell Reports doi:10.1016/j.celrep.2018.09.086 [GeneHero™ clone expressing sgRNA targeting Meis1]
• Chua, M.D., et al. (2018). Klebsiella pneumoniae disassembles host microtubules in lung epithelial cells. Cellular Microbiology doi: 10.1111/cmi.12977 [GeneHero™ clones expressing sgRNA targeting KANAL1, KATNB1]
• Raas, Q., et al. (2018). A microglial cell model for acyl-CoA oxidase 1 deficiency. BBA – Molecular and Cell Biology of Lipids doi: 10.1016/j.bbalip.2018.10.005 [GeneHero™ clone expressing sgRNA targeting Acox1]

• Lo, C.L., et al. (2017). Epigenetic Editing of Ascl1 Gene in Neural Stem Cells by Optogenetics. Scientific Reports DOI: 10.1038/srep42047 [Genome-TALER™ clone targeted to Ascl1]
• Teng, Y., et al. (2017). MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression. Nature Communications DOI: 10.1038/ncomms14448  [Lentiviral particles expressing sgRNA targeting MVP]
• Shen, J.P., et al. (2017). Combinatorial CRISPR–Cas9 screens for de novo mapping of genetic interactions. Nature Methods DOI: 10.1038/nmeth.4225 [HeLa, HEK293T and A549 Cas9-expressing stable cell lines]
• Blanco, G., et al. (2017). IGFN1_v1 is required for myoblast fusion and differentiation. PLoS ONE, In press. [sgRNA and donor clones targeting Igfn1 exon 13]
• Ji, Q., et al. (2017). Genetically engineered cell lines for α1-antitrypsin expression. Biotechnology Letters DOI: 10.1007/s10529-017-2391-5 [Genome-CRISP™ human AAVS1 Safe Harbor Knock-in kit and AAT knock-in ORF donor clone].
• Jin, K., et al. (2017). Crosstalk between stromal components and tumor cells of TNBC  via secreted factors enhances tumor growth and metastasis. Oncotarget DOI:10.18632/oncotarget.19417 [Genome-CRISP™ sgRNA clones targeting CXCR2]
• Leonova, K., et al. (2017). Transcription of Repeats Activates  INterfern (TRAIN) in response to  chromatin destabilization induced with anti-cancer small molecule, bioRxiv DOI: 10.1101/142471 [Genome-CRISP™ sgRNA clones targeting ZBP1]
• Bartolomeo, R., et al. (2017). mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. The Journal of Clinical Investigation DOI: 10.1172/JCI94130 [Genome-CRISP™ sgRNA clone targeting Gusb]
• Morita, M., et al. (2017). mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1. Molecular Cell DOI: 10.1016/j.molcel.2017.08.013 [Genome-CRISP™ sgRNA clones targeting 4E-BP1 and 4E-BP2]
• Murao, N., et al. (2017). Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β -cell glutamate signaling for incretin-induced insulin secretion. PLoS ONE DOI: 10.137 1/journal.pone.01872 [Cas9 D10 nickase expression clone and sgRNA expression clones]
• Borque, C., et al. (2017). H2S protects lipopolysaccharide-induced inflammation by blocking NFκB transactivation in endothelial cells. Toxicology and Applied Pharmacology DOI: 10.1016/j.taap.2017.11.004 [Genome-CRISP™ CRISPR-Cas9 clone for CSE gene knockout]
• Fan, Q., et al. (2017). The novel ZIP4 regulation and its role in ovarian cancer. Oncotarget DOI: 10.18632/oncotarget.21435 [ZIP4 and PPARr lentiviral CRISPR vectors]
• Sun, X., et al. (2017). Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP-Activated Protein Kinase. Molecular Nutrition and Food Research DOI: 10.1002/mnfr.201700536 [AMPK CRISPR vectors]
• Huang, F., et al. (2017). δCatenin promotes tumorigenesis and metastasis of lung adenocarcinoma. Oncology Reports DOI: 10.3892/or.2017.6140 [Genome-CRISP™ CRISPR-Cas9 clone for Ctnnd2 gene knockout]
• Shuang, T., et al. (2017). The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells. Biochemical Pharmacology DOI: 10.1016/j.bcp.2017.12.009 [Genome-CRISP™ CRISPR-Cas9 clone for IGF-1R gene knockout]
• Jin, L., et al. (2017). The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Molecular Cell DOI: 10.1016/j.molcel.2017.11.025 [Genome-CRISP™ CRISPR-Cas9 clones for LKB1 and CamKK2 gene knockout]
• Ikeda, M., et al. (2017). Correction of a Disease Mutation using CRISPR/Cas9-assisted Genome Editing in Japanese Black Cattle. Scientific Reports DOI: 10.1038/s41598-017-17968-w [IndelCheck™ Insertion/deletion detection system]

• Qi, C., et al. (2016) HEK293T Cells Are Heterozygous for CCR5 Delta 32 Mutation. PLOS ONE, April 4, 2016 https://doi.org/10.1371/journal.pone.0152975. [T7E1 nuclease].
• Hsu, PY., et al. (2016) Spatiotemporal control of estrogen-responsive transcription in ERα-positive breast cancer cells. Oncogene, 35, 2379–2389; DOI:10.1038/onc.2015.298; published online 24 August 2015. [DEREs, sgRNA contructs and validation].
• Blackburn, JB., et al. (2016) COG Complex complexities: Detailed characterization of a complete set of HEK293T cells lacking individual COG subunits. Frontiers in Cell and Developmental Biology, 2016; 4: 23. [Cog5, Cog2, Cog7 sgRNA].
• Hu, B., et al. (2016). A Novel Missense Mutation of CMT2P Alters Transcription Machinery. Annals of Neurobiology DOI: 10.1002/ana.24776 [LRSAM1 CRISPR sgRNA clone]
• Bahal, R., et al. (2016). In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nature Communications DOI: 10.1038/ncomms13304 [Cas9 and sgRNA clones targeting mouse b-globin]

• Zhang, J., et al. (2015) Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene, 35, 1926-1942 (14 April 2016) | DOI:10.1038/onc.2015.256. [CRISPR-Cas9 genome editing system for FAK]
• Wu, J., et al. (2015) Decreased RECQL5 correlated with disease progression of osteosarcoma. Biochemical and Biophysical Research Communications, Volume 467, Issue 4, 27 November 2015, Pages 617–622. [AAVS1 safe harbor gene knock-in kit]
• Foss, O., et al. (2015) Role of FOXA genes in maintaining transformed phenotype in human bronchial epithelial cells. NTNU Open, 2015. [FOXA1 gene, sgRNA, donor, AAVS1 safe harbor gene knock-in kit].

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